A novel allele frequency trajectories template to discriminate genetic similarity among populations

Publication date: Available online 13 October 2018Source: Meta GeneAuthor(s): Sagy Elzalabany, Tarek Taha, Sahar Fawzi, Olfat ShakerAbstractPopulations' allele frequency studies are one of the major topics of Population genetics. In this research, an Allele Frequency Quality Control System (AFQCS) is proposed as a verification tool for populations' genetics data. This system visualizes and analyses statistically the allele frequencies of 15 Short Tandem Repeats (STRs) autosomal loci based on 65 previously published population genetics studies. Allele Frequency Trajectories (AFTs) for all addressed populations were plotted. The AFTs showed a distinct trend for each locus, which was used to build a global reference template for these loci. Pearson's Correlation Coefficient Matrices (CCM) generated for each locus were used to calculate different statistical parameters to assess the genetic populations' relationships, such as histogram, median, interquartile range, and p-value.P-values and interquartile ranges supported the visualization results by indicating the presence of a global AFT pattern for each locus. The novel developed AFTs template illuminates the idea of the first quality control system for testing new datasets, based on the high genetic similarity among populations. From CCMs statistical results, wide spectrums recorded in loci TH01, D13S317, D2S1338, D18S51, and FGA indicate significant populations' genetics heterogeneity.

Source: Meta Gene - October 13, 2018 Category: Genetics & Stem Cells Source Type: research