The Merchants of Death

It occurs to me that a cheap trick to get blog material is to tell you what I lectured about yesterday. Most weeks I lecture Monday Wednesday and Friday, although I have guest lecturers when I can because I'm lazy and the students would get sick of me anyway. But Friday I talked about the tobacco industry.In 1953, British scientists Doll and Hill published the results of a cohort study that showed that smoking tobacco causes lung cancer. Evidence quickly piled up that it also caused heart disease. Tobacco company scientists got right away that this was all true, and told the executives. (I'll tell you how we know this in a minute.) But the companies denied it, and called it junk science. The first Surgeon General's report on smoking and health came out in 1964, and concluded that tobacco causes cancer and heart disease and chronic obstructive pulmonary disease, but the companies continued to deny it, even as their own scientists were writing internal memos urging them to own up to it and try to make safer cigarettes. (No, they didn't go public and they kept on taking their salaries. Just sayin'.)The tobacco companies set up a fake research institute, surreptitiously through a law firm, and funded scientists to do research that came to conclusions favorable to the industry. A priority for them at this time was denying that environmental tobacco smoke is dangerous because that created risk of workplace smoking bans and other actions that would de-normalize smoking. (If you're t...
Source: Stayin' Alive - Category: American Health Source Type: blogs

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CONCLUSIONS Matricine induced antiproliferative effects in capan-2 human pancreatic cancer cells through inducing apoptosis, caspase activation, inhibition of cell migration and invasion, and blocking the mTOR/PI3K/AKT signalling pathway. PMID: 31005960 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS In conclusion, in view of the results of this study, it might be suggested that ferruginol might serve as an essential lead molecule for the treatment of thyroid cancer provided further in-depth studies especially studying ferruginol toxicological as well as in vivo studies are needed. PMID: 31005958 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Should we abandon the term〝lone atrial fibrillation〞? Hellenic J Cardiol. 2019 Apr 17;: Authors: Lin KB, Marine JE, Calkins H, Nazarian S, Wei M, Huang MD, Li JB Abstract Characterized by lack of evidence of structural heart disease or any secondary causes of atrial fibrillation (AF), "lone AF" used to represent a unique subtype of AF among the young individuals who were under the age of 60. Despite the longstanding definition has been proposed for years, the diagnostic criteria for "lone AF" remain ambiguous. As more contributing factors causing AF are recognized gradually, the...
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Publication date: Available online 21 April 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Massimo Libra, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Weifeng Mao, Heng-Liang LinAbstractPancreatic cancer is devastating cancer worldwide with few if any truly effective therapies. Pancreatic cancer has an increasing incidence and may become the sec...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
In this study, we designed pH and redox dual-stage responsive nanocarriers in the different delivery stages for co-delivery phosphorylated curcumin (p-Cur) with doxorubicin (Dox). The MSNs nanocarriers were functionalized via specific cleavable PEGylation and hydrogel coating crosslinked by disulfide bonds: MSNs as core load Dox; p-Cur encapsulated in hydrogel coating. In blood circulation, PEGylation endow the nanocarriers with long time during blood circulation; while in tumor tissue, PEG shells could be cleaved due to the pH-sensitive bond and expose the cationic hydrogel coating to improve cell uptake; while inside tum...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 21 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Margaux Elie, Gilbert Umuhire Mahoro, Eric Duverger, Jean-Luc Renaud, Richard Daniellou, Sylvain GaillardAbstractCytotoxicity of cationic (NHC)Cu(I) complexes bearing 2,2′-dipyridylamine (dpa) type ligands has been evaluated toward 4 cancer cell lines, and compared to the one of neutral (NHC)Cu(I) complexes. The high cytotoxicity of these novel cationic (NHC)Cu(I) complexes, combined with the straightforward synthesis, and versatility of dpa type ligands may offer new prospects in cancer research, toward the developm...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
ConclusionsWe provided further evidences for implication of miR-100 and mTOR pathway in breast cancer pathogenesis.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
BACKGROUND: Drug consumptions rooms (DCRs) are a well-established and evidence-based harm reduction response to drug use. Recently, a consortium led by health services in Glasgow, United Kingdom (UK), proposed piloting a DCR. In this article, we examine ho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Two seemingly associated demographic trends have generated considerable interest: income stagnation and rising premature mortality from suicides, drug poisoning, and alcoholic liver disease among US non-Hispanic Whites with low education. Economists interp...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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