Sub-lethal doses of surotomycin and vancomycin have similar effects on Clostridium difficile virulence factor production in vitro.

CONCLUSION: In summary, these findings demonstrate that surotomycin and vancomycin have similar effects on exotoxin production and sporulation by C. difficile in vitro. Furthermore, since spores contribute to recurrent infection, the ability of surotomycin to suppress spore formation may explain its ability to disrupt the reinfection cycle in the clinical setting. PMID: 30307842 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30307842?dopt=Abstract

Source: Journal of Medical Microbiology - October 11, 2018 Category: Microbiology Authors: Aldape MJ, Rice SN, Field KP, Bryant AE, Stevens DL Tags: J Med Microbiol Source Type: research