Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters.

CONCLUSION: The reported new compounds act on hMATs as well as the structures of the transporters complexed with diverse ligands by either experiment or computational modeling have shed light on the poly-pharmacology, multimodal and allosteric regulation of the drugs to transporters. All of the studies will greatly promote the structure-based drug design (SBDD) of structurally novel scaffolds with high activity and selectivity for hMATs.
PMID: 30306851 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - October 9, 2018 Category: Chemistry Authors: Xue W, Fu T, Zheng G, Tu G, Zhang Y, Yang F, Tao L, Yao L, Zhu F Tags: Curr Med Chem Source Type: research