Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates.

Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates.
Chem Commun (Camb). 2018 Oct 10;:
Authors: Yang Y, Yang W
Abstract
Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.
PMID: 30302489 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 10, 2018 Category: Chemistry Authors: Yang Y, Yang W Tags: Chem Commun (Camb) Source Type: research