Is the next big step in cancer therapy personalized vaccines?
(University of California - San Diego) Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
Cell Proliferation, EarlyView.
AbstractEvery biological fluid, blood, interstitial fluid and lymph, urine, saliva, lacrimal fluid, nipple aspirate, and spinal fluid, contains a peptidome-degradome derived from the cellular secretome along with byproducts of the metabolic/catabolic activities of each parenchymal organ. Clement et al. (J Proteomics 78:172 –187,2013), Clement et al. (J Biol Chem 291:5576 –5595,2016), Clement et al. (PLoS One 5:e9863,2010), Clement et al. (Trends Immunol 32:6 –11,2011), Clement et al. (Front Immunol 4:424,2013), Geho et al. (Curr Opin Chem Biol 10, 50 –55,2006), Interewicz et al. (Lymphology 37:65 ‚Ä...
An Oregon teenager’s innovation could change the way doctors treat pancreatic cancer, a deadly form of the disease that has just a 7% five-year survival rate. Rishab Jain, a 13-year-old from Stoller Middle School in Portland, on Tuesday won the Discovery Education 3M Young Scientist Challenge with an algorithm that uses machine learning to help doctors zero in on the pancreas during cancer treatment. Doing so can be difficult, since the pancreas is often obscured by other organs, and since breathing and other bodily processes can cause it to move around the abdominal area. As a result, doctors sometimes need to deplo...
Conditions: Pancreatic Carcinoma; Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type Interventions: Procedure: Optical Coherence Tomography; Procedure: Therapeutic Conventional Surgery; Diagnostic Test: Laboratory Evaluation Sponsors: Ohio State University Comprehensive Cancer Center; National Cancer Institute (NCI) Not yet recruiting
Conclusions: The diagnosis of obesity, especially morbid obesity, was associated with a significantly earlier gastrointestinal cancer onset in California. Further research with prospective cohort data may be required to establish the causal relationship between obesity and cancer onset age. PMID: 30327727 [PubMed - in process]
(Universit é de Gen è ve) Among several forms of pancreatic cancer, one of them affects specifically women, often young, even though the pancreas is an organ with little exposure to sex hormones. This pancreatic cancer, known as 'mucinous cyst,' has strange similarities with another mucinous cancer, affecting the ovaries. By conducting large-scale analyses of genomic data, researchers at the University of Geneva and at the University Hospitals of Geneva have provided an answer: both tumors originate from embryonic germ cells.
esinger The interaction with platelets is of crucial importance for tumor cells passing through hematogenous metastasis. Platelets protect cancer cells from immune surveillance and exhibit many other prometastatic effects. Notably, platelets can change the epithelial tumor phenotype, a process termed epithelial-mesenchymal transition (EMT), which confers stem cell-like properties onto tumor cells associated with an increased motility and drug resistance. The aim of the study is to investigate the impact of heparin on the platelet induced EMT program in pancreatic and prostate tumor cells. Platelet activation and intera...
Optimizing the outcomes of pancreatic cancer surgery, Published online: 19 October 2018; doi:10.1038/s41571-018-0112-1Successful surgical resection offers patients with pancreatic cancer the best chance of survival. However, many patients do not have surgically resectable disease. In this Review, the authors describe recent improvements in pancreatic cancer surgery, which have increased survival and also enabled more patients to undergo surgery.
The treatment approach to node-positive gallbladder cancer has unresolved issues with regard to the management of patients with a positive superior retro-pancreatic (level 13a) node, which is the highest level of spread. The American Joint Committee on Cancer remains unclear on the status of the 13a node.
Digestive Endoscopy,Volume 0, Issue ja, -Not available-.