Is the next big step in cancer therapy personalized vaccines?

(University of California - San Diego) Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Conclusion: The present study indicates that preoperative 3D-measured RPV is predictive of POPF after PD.Gastrointest Tumors
Source: Gastrointestinal Tumors - Category: Gastroenterology Source Type: research
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc‑1 cancer stem‑like cells. Oncol Rep. 2018 Dec 06;: Authors: Peng G, Tang Z, Xiang Y, Chen W Abstract Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchymal transition (EMT), which has been reported to promote can...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Association between interleukin‑33 and ovarian cancer. Oncol Rep. 2018 Dec 07;: Authors: Liu X, Hansen DM, Timko NJ, Zhu Z, Ames A, Qin C, Nicholl MB, Bai Q, Chen X, Wakefield MR, West G, Fang Y Abstract Ovarian cancer is the leading cause of cancer‑ associated mortality in the female reproductive system. Interleukin (IL)‑33 and its receptor IL 1 receptor like 1 (also termed ST2) are expressed by many cell types including epithelial cells. The role of IL‑33 in the pathogenesis of neoplasia remains controversial. The authors previously demonstrated that IL‑33 inhibits the growth of pancreatic ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis. Oncol Rep. 2018 Nov 28;: Authors: Ma J, Xue M, Zhang S, Cheng L, Qian W, Duan W, Shen X Abstract Resveratrol is a type of polyphenol that is abundantly present in knotweed and grapes, and has been confirmed to have tumor‑inhibitory properties. However, the effect of resveratrol on tumor cells under chronic stress conditions remains unclear. The aim of the present study was to demonstrate that resveratrol exerts a significant inhibitory effect on the growth and proliferation of tumor cells under...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Conclusions: High miR-93 and miR-200a levels in cancer cells of PDAC were associated with better differentiation, and miR-200a expression in benign tissue with excellent RFS. Keap1 and Nrf2 mRNA levels showed prominent down-regulation in cancerous versus benign tissue, but they were not associated with disease aggressiveness or outcome.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Pancreatic inflammation (either focal or involving the whole gland) lowers the diagnostic sensibility of EUS in the work- up of pancreatic masses suspected for cancer, requiring further invasive diagnostic methods. Focal autoimmune pancreatitis and paraduodenal pancreatitis are still confused with pancreatic cancer, even in the absence of pancreatic inflammation. PMID: 30534648 [PubMed - in process]
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Pancreatic cancer is one of the most common cancers worldwide, with a 5-year survival rate of approximately 7%, and for most patients, death occurs within 6months after the diagnosis [1]. As in most other countries, the health burden of pancreatic cancer in China is on the rise, with annual mortality rates nearly equal to the incidence [2]. According to GLOBOCAN 2012 [3], it was estimated that China accounted for 19.5% (65727/337872) of all newly diagnosed pancreatic cancer cases and 19.3% (63662/330391) of all deaths from pancreatic cancer worldwide.
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
CONCLUSIONS: MiR-142 over-expression weakened ADM resistance in pancreatic cancer cells by targeting DJ-1 to enhance PTEN expression and attenuate PI3K/AKT signaling pathway activity. PMID: 30536312 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSION: Pancreatic cancer mortality is unequally distributed across Brazilian regions and genders, and during the next two decades the differences will be accentuated.RESUMO CONTEXTO: O c âncer de pâncreas é uma das principais causas de morte relacionadas ao câncer em países desenvolvidos, e uma das neoplasias malignas mais letais. Este tipo de câncer é classificado como o nono mais frequente do mundo. OBJETIVO: Analisar as tendências temporais do câncer de pâncreas no Br asil no período de 2000-2014, e calcular as projeções de mortalid...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
Ali Vaziri-Gohar, Mahsa Zarei, Jonathan R. Brody, Jordan M. Winter
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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