Is the next big step in cancer therapy personalized vaccines?

(University of California - San Diego) Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Wantong Yao, Anirban MaitraIn this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
Source: Cell - Category: Cytology Source Type: research
Authors: Hopancı Bıçaklı D, Çehreli R, Özveren A, Meseri R, Uslu R, Karabulut B, Akçiçek F Abstract Background/aim: The purpose of this study was to determine sarcopenia, sarcopenic obesity and phase angle (PA) and the influence of chemotherapy (CT) on anthropometric measurements and and the PA in in geriatric patients with gastrointestinal (GI) cancer. Materials and methods: The anthropometric measurements, calf circumference (CC), upper midarm circumference (UMAC), and hand grip strength (HGS), have been measured to understand muscle function of 153 patients (mean age of 70...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Marcellinus Franciscus (Marcel) Jonkman, MD, PhD, an esteemed colleague and friend, died in Groningen, the Netherlands, on January 14, 2019, from complications of pancreatic cancer.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: In Memoriam Source Type: research
In conclusion, our study provides a protocol of producing a biologically active survivin-targeting macromolecule, T34A-C84A-dNSur-His, which can be used as a tool for studying the molecular and cellular roles of survivin in cells. T34A-C84A-dNSur-His is also a potential therapeutic agent for augmenting cancer therapy.
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Image-guided radiation therapy developer ViewRay has signed a distribution...Read more on AuntMinnie.comRelated Reading: ViewRay secures FDA clearance for MRIdian upgrades New orders drive ViewRay revenue growth in 2018 ViewRay adds to revenue and net loss in Q3 ViewRay to launch pancreatic cancer trial ViewRay taps new CCO
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
In conclusion, our findings indicate that targeting miR-142-5p may provide a novel strategy for the treatment of pancreatic cancer.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study aimed to investigate the role and regulatory mechanism of CypB in NSCLC progression. The expression levels of CypB was detected in NSCLC samples and cell lines by ELISA, western blot and immunohistochemistry assay. In addition, CCK8, colony formation, scratch and transwell assays were used to evaluate the proliferation, migration and invasion of A549 cells with CypB silencing. The expression of angiogenesis related proteins and pathway-related factors were detected by western blot. In NSCLC samples, CypB expression was upregulated. The expression of CypB was significantly reduced in the siRNA-cyclophilin B group...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Image-guided radiation therapy developer ViewRay has signed a distribution...Read more on AuntMinnie.comRelated Reading: ViewRay secures FDA clearance for MRIdian upgrades New orders drive ViewRay revenue growth in 2018 ViewRay adds to revenue and net loss in Q3 ViewRay to launch pancreatic cancer trial ViewRay taps new CCO
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Conclusions: Return of IRR in conjunction with cancer prevention counseling led to low levels of test-specific distress and uncertainty among carriers. No other adverse psychological outcomes were observed.Public Health Genomics
Source: Public Health Genomics - Category: Genetics & Stem Cells Source Type: research
In conclusion, the amino acid 1,199 of nestin is localized in the tail structure of the filament and polymerizes with other intermediate filament proteins. The present results suggest that missense variations of nestin affect pancreatic carcinogenesis in Japanese patients. PMID: 30988821 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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