DeepSpine AI enhances grading of lumbar spinal stenosis

An artificial intelligence (AI) algorithm called DeepSpine can assist radiologists...Read more on AuntMinnie.comRelated Reading: AI can't replace radiologists for chest x-ray reads MRI-based AI could predict Alzheimer's progression AI, diffusion MRI can predict outcomes for epilepsy Can AI predict outcomes for psychosis, depression? NYMIIS: Next-gen PACS will include 'best-of-breed' AI
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Conclusion: The decision-to-delivery interval was ≤ 15 min in most women, suggesting that optimised organisation ensures short decision-to-delivery interval independently of the anaesthetic technique performed. As general anaesthesia was associated with worse neonatal outcomes, our results support the early insertion of an epidural catheter whenever there is any potential concern that an emergency caesarean section may be required.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 24 May 2019Source: Journal of Psychiatric ResearchAuthor(s): Laura D. Crocker, Sarah M. Jurick, Kelsey R. Thomas, Amber V. Keller, Mark Sanderson-Cimino, Samantha N. Hoffman, Briana Boyd, Carie Rodgers, Sonya B. Norman, Ariel J. Lang, Elizabeth W. Twamley, Amy J. JakAbstractSome providers have expressed hesitation about the appropriateness of PTSD treatment for veterans with a history of mild traumatic brain injury (mTBI), given concerns that TBI-related sequelae may negatively affect PTSD treatment and/or should be the focus of treatment instead. However, research suggests that those wit...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
ConclusionMethods:The two alleles of ApoE (E3 and E4) differ in one nucleotide. Based on this single-nucleotide polymorphism (SNP), we designed a novel “clustered regularly interspaced short palindromic repeats” (CRISPR) based system that specifically recognizes, binds and targets the ApoE4 allele for knockout by using the VRER CRISPR associated protein 9 (Cas9) variant.Results and conclusionApplication of this approach in mice astrocytes expressing the human ApoE3 or ApoE4 resulted in a significant decrease of ApoE4 protein levels (-70%) without any significant changes in ApoE3 levels. The cell-culture experim...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe used gold nanoparticles loaded exosomes for in-vivo neuroimaging and present specific migration and homing to various brain pathologies including stroke, Parkinson's, Alzheimer's, Autism and healthy brains as a control. By this method, we visualized the migration and homing abilities of exosomes in long-term follow-up ad report that in pathological areas they home for more than 96 hours while in healthy brains they are being evacuated within 24 hours. Furthermore, we show that MSC-exo uses chemotaxis signaling to target the inflammatory areas in the brain.
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe used the CRISPR-Cas9 system to knock down the small subunit of the calpain protein in mice astrocytes expressing either the human ApoE3 or ApoE4 alleles. We then investigated, the resulting effects of the Calpain knock down on the expression of autophagy-related proteins and on the uptake of fluorescent Aβ.We found that the levels of mitofusin1, a protein responsible for the fusion and integrity of the mitochondria and p62 a protein that undergoes degradation during autophagy, are higher in the ApoE4 compared to ApoE3. However, in astrocytes treated with CRISPR-Cas9, which reduced the levels calpain by 75...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionFor that purpose, we subjected 5XFAD mice to myeloablative irradiation and bone marrow-repopulation from MPO Knock-out (KO) mice to form 'MPO KO-5XFAD' mice. MPO KO-5XFAD mice exhibited improvement in their risk assessment behavior, as measured by the 'Elevated plus maze/ test and the 'Open field' test, when compared to 5XFAD mice transplanted with WT cells (termed 'WT-5XFAD'). Remarkably, MPO KO-5XFAD mice also showed improved spatial recognition and learning, as was evident in the 'Y-maze' test, the 'Morris water maze' test and by 'Contextual fear conditioning' test. Hippocampal RNA expression analysis by QPCR ...
Source: Cytotherapy - Category: Cytology Source Type: research
Dr Peter Yellowlees on the critical concerns that a new systematic review and simulation study reveal about these models.Medscape Psychiatry
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry Commentary Source Type: news
Publication date: Available online 24 May 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Mathilde Septier, Coline Stordeur, Junhua Zhang, Richard Delorme, Samuele CorteseAbstractThe relationship between ADHD and suicidal spectrum behaviors (SSBs) remains uncertain. We conducted the first meta-analysis on the association between ADHD and SSBs taking possible confounders into account. Based on a pre-registered protocol (PROSPERO-CRD42018093003), we searched Pubmed, Ovid and Web of Knowledge databases through April 6th, 2018, with no language/publication type restrictions, and contacted study authors for unpubl...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 23 May 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Lea Boecker, Paul PauliAbstractStartle reflex potentiation versus startle attenuation to unpleasant versus pleasant stimuli likely reflect priming of the defensive versus appetitive motivational systems, respectively. This review summarizes and systemizes the literature on affective startle modulation related to psychopathologies with the aim to reveal underlying mechanisms across psychopathologies. We found evidence for psychopathologies characterized by increased startle potentiation to unpleasant stimuli (anxiety diso...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
You’ve been diagnosed with bipolar disorder, or maybe your loved one has. And you’re wondering, what’s the best treatment? What actually works? What the heck do I do? Because bipolar disorder is a chronic, complex condition, managing it can feel overwhelming and downright confusing. But thankfully there are effective, research-based treatments that really work. Medication is the mainstay of treatment. However, the best way to treat bipolar disorder is with a comprehensive approach, which includes “ongoing psychosocial interventions to help maintain health and to respond to breakthrough symptoms whe...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Disorders General Psychotherapy Self-Help Treatment Bipolar Disorder bipolar disorder treatment Cbt IPSRT managing bipolar disorder opposite action Source Type: news
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