Postural Orthostatic Tachycardia in a Patient with Type 2 Diabetes with Diabetic Neuropathy.

Postural Orthostatic Tachycardia in a Patient with Type 2 Diabetes with Diabetic Neuropathy. Int Heart J. 2018 Oct 10;: Authors: Tomichi Y, Kawano H, Mukaino A, Chiba A, Doi Y, Arakawa S, Ishimatsu T, Fukae S, Abiru N, Maemura K Abstract A 24-year-old Japanese man with type 2 diabetes mellitus and diabetic neuropathy was admitted to our ward to evaluate the cause of orthostatic intolerance. During a head-up tilt test, his heart rate increased from 105 to 155 beats/minute within 3 minutes, and chest discomfort began. He was diagnosed with postural orthostatic tachycardia syndrome (POTS), and orthostatic intolerance disappeared after β-blocker treatment. Scintigraphy using 123I-metaiodobenzylguanidine showed decreased cardiac uptake. Power spectral analysis of heart rate variability for 24 hours in Holter electrocardiography demonstrated decreases in both sympathetic and parasympathetic nervous system activities, with a greater decrease in parasympathetic activity than sympathetic activity. The relative sympathetic hyperactivity in the present patient with diabetic neuropathy seemed to be related to POTS. PMID: 30305583 [PubMed - as supplied by publisher]
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research