Dramatic drop in public confidence after Philippines dengue vaccine controversy

(Taylor&Francis Group) The Philippines' highly politicised response to newly-reported risks of a dengue vaccine led to a dramatic drop in public trust in vaccines overall, according to new research published in Human Vaccines&Immunotherapeutics.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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By MARC M. BEUTTLER, MD Every year at this time, you hear warnings that flu season has arrived. New data from the CDC indicates the season is far from over. So, you are urged by health authorities to get a flu shot. What you may not realize is how the flu can affect the hospitals you and your loved ones rely on for care.   In January, the large urban hospital where I am an intern faced the worst flu outbreak it has ever seen. Nearly 100 staff members tested positive for the flu. Residents assigned to back-up coverage were called to work daily to supplement the dwindling ranks of the sick. Every hospital vis...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Hospitals Medical Practice Marc Beuttler Vaccination Source Type: blogs
Conclusions. The IgG avidity assay accurately distinguished recent ZIKV from past DENV infections in patients who traveled to dengue endemic regions. This assay could be very useful in patients with high risk of Zika complications such as pregnant women and monitoring immune responses in vaccine trials.
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research
by T. Alex Perkins, Robert C. Reiner, Guido Espa ña, Quirine A. ten Bosch, Amit Verma, Kelly A. Liebman, Valerie A. Paz-Soldan, John P. Elder, Amy C. Morrison, Steven T. Stoddard, Uriel Kitron, Gonzalo M. Vazquez-Prokopec, Thomas W. Scott, David L. Smith Prophylactic vaccination is a powerful tool for reducing the burden of infectious diseases, due to a combination of direct protection of vaccinees and indirect protection of others via herd immunity. Computational models play an important role in devising strategies for vaccination by making proje ctions of its impacts on public health. Such projections are subject...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
This study provides a transcriptomic definition of DENV-specific activated human CD8+ T cell subsets and defines a benchmark profile that vaccine-specific responses could aim to reproduce.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 13 March 2019Source: Journal of Theoretical BiologyAuthor(s): Sourav Kumar Sasmal, Yasuhiro Takeuchi, Shinji NakaokaAbstractDengue infection results in a significant number of deaths, mostly in the tropical and subtropical regions across the world. Yet, despite the seriousness of this disease, vaccine, and antiviral drugs that could be employed in dengue treatment remain elusive. The desire to establish the factors determining the disease severity and the growing need for efficient drugs has prompted extensive research interest in within-host viral dynamics. However, very few mathematical...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Abstract Zika and the four serotypes of dengue are closely related flaviviruses that share a high degree of structural and sequence homology and co-circulate in many regions of the world. Here, we review recent studies investigating antigenic cross-reactivity between the two viruses. We discuss the pathogenic and protective roles of cross-reactive anti-viral antibody and T cell responses, respectively, in modulating the outcome of secondary dengue or Zika infection. Based on recent findings and increased incidence of severe disease in seronegative recipients of the first dengue vaccine to be licensed, we propose t...
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Editorial Source Type: research
asad Dash Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental for preclinical investigations. Human viruses, however, seldom infect mice due to differences in the cellular receptors used by the viruses for entry, as well as in the innate immune responses in mice and humans. In other words, a species barrier exists when using mouse models for investigating human viral infections. Developing transgenic (Tg) mice models expressin...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
With India described as the epicenter of dengue, contributing significantly to the global dengue epidemic, the country is also poised to play a key role in contributing towards the WHO 2020 targets of reducing dengue deaths by 50% and dengue cases by 25%. This Supplement seeks to integrate research findings within India, provide a platform for dissemination of current dengue research, and encourage future dengue control activities under the leadership of the Indo-US Vaccine Action Program and the Indian government .
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
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