Gut Microbiota Signature Altered in Alzheimer's Disease Gut Microbiota Signature Altered in Alzheimer's Disease

The composition of gut microbiota is altered in patients with Alzheimer's disease, potentially supporting the inflammatory theory of the disease's pathogenesis, new research suggests.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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Objective: The present study investigates viscoelastic properties of human autopsy brain tissue via nanoindentation to find feasible biomarkers for Alzheimer's disease (AD) in $ex$ $vivo$ condition and to understand the mechanics of the human brain better, especially on the difference before and after progression of AD. Methods: Viscoelastic properties of paraformaldehyde-fixed, paraffin-embedded thin (8 $mu text{m}$) sectioned normal and AD affected human autopsy brain tissue samples are investigated via nanoindentation with a combined loading profile of a linear preloading and a sinusoidal loading at various loadi...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 19 May 2019Source: Neuroscience LettersAuthor(s): Laia Pérez-Roca, Patricia Prada-Dacasa, Cristina Segú-Vergés, Ana Gámez-Valero, María A. Serrano-Muñoz, Cristina Santos, Katrin BeyerMutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and transcription factor EB (Tfeb) regulates lysosomal prot...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
...Developing dementia doesn’t take away your individuality or humanity any more than developing cancer or diabetes. Therefore, rather than concentrate only on drugs, we need to help caregivers – and yes professionals – better understand how to help people living with dementia cope with the negative aspects of their illness so that they can live the best life that they can. Read more about the spectrum of Alzheimer's disease (and hope) on HealthCentral: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Resource Center Support a caregiver or jump-start discussion in support groups ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractDiabetes mellitus is metabolic syndrome and a risk factor for cognitive dysfunction-related diseases such as dementia, especially Alzheimer ’s disease (AD), which is associated with chronic inflammation and abnormal insulin signaling pathway. Exercise, a known potential therapy for diabetes, can also alleviate neurodegeneration. We evaluated the effects of aerobic exercise on inflammation and insulin signaling pathway in the prefronta l cortex of diabetic rats. Male SD rats were fed with a normal diet or a high-fat diet (HFD) for 8 weeks. Then, part of the HFD rats was selected for aerobic exercise train...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
This study uses a qualitative computational approach—combining temporal and semantic information—to investigate exploitation and exploration patterns as indicators for semantic memory retrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94 years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and education. All groups produced, on average, the same amount of semantically related items in rapid succession within word clusters. Conversely, towards AD, there was a clear decline in semantic as well as...
Source: Neuropsychologia - Category: Neurology Source Type: research
Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesis led to the development of four cholinesterase inhibitors. These compounds can bring prolongation of the symptom-free period in some patients. This is the first report directly comparing donepezil and rivastigmine plasma and brain levels in in vivo study. Donepezil and rivastigmine were applied i.m. to rats; the dose was calculated from clinical recommendations. The samples were analysed on an Agilent 1260 Series LC with UV/VIS detector. An analytical column (Waters Spherisorb S5 W (250 mm× 4.6 i.d.; 5μm particle siz...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Conditions:   Alzheimer Dementia;   Alzheimer Disease Intervention:   Drug: Contraloid Sponsors:   Prof. Dr. Dieter Willbold;   Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany;   Medical University of Vienna;   NeuroScios, Austria;   Nuvisan, Germany;   Fundación Teófilo Hernando, Spain;   Alzheimer's Association Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In past years, there has been considerable discussion of Alzheimer's disease as a type 3 diabetes
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Abstract OBJECTIVE: Investigate Vitamin D3 (VD3) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD3 (21 days). METHODS: Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12.5 μg/kg, STZ+VD42 μg/kg, STZ+VD125 μg/kg. RESULTS: VD3 prevented the increase in AChE in groups of VD42 µg/kg and VD125 µg/kg; in AChE of synaptossom...
Source: Redox Report : communications in free radical research - Category: Biochemistry Authors: Tags: Redox Rep Source Type: research
Traumatic brain injury (TBI) is a major cause of death and disability in the United States, where 1.4 million people sustain a TBI annually and 3 to 5 million are currently living with a TBI-associated disability. Concussions are a common component of TBI. Severe TBI, such as events that involve a loss of consciousness, has received a lot of attention; it is known that athletes who experience a high rate of these events have an increased risk of chronic traumatic encephalopathy. What is less known is the short-term and long-term effects of events that do not involve a loss of consciousness. One of the most feared long-term...
Source: JAMA Neurology - Category: Neurology Source Type: research
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