Amixicile reduces severity of cryptosporidiosis, but does not have in vitro activity against Cryptosporidium.

Amixicile reduces severity of cryptosporidiosis, but does not have in vitro activity against Cryptosporidium.
Antimicrob Agents Chemother. 2018 Oct 08;:
Authors: Bartelt LA, Bolick DT, Kolling GL, Stebbins E, Huston CD, Guerrant RL, Hoffman PS
Abstract
Cryptosporidium causes significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here we show that amixicile, a highly selective water soluble derivative of NTZ diminishes Cryptosporidium severity in a malnourished mouse model despite a lack of direct anti-cryptosporidial activity. We suggest that amixicile; by tamping down anaerobes associated with intestinal inflammation, reverses weight loss and indirectly mitigates infection-associated pathology.
PMID: 30297368 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - October 8, 2018 Category: Microbiology Authors: Bartelt LA, Bolick DT, Kolling GL, Stebbins E, Huston CD, Guerrant RL, Hoffman PS Tags: Antimicrob Agents Chemother Source Type: research