Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.

In conclusion, the activation of TRPV3 aggravated pathological cardiac hypertrophy through calcineurin/NFATc3 signalling pathway and correlated with the protein expression levels of calcineurin, phosphorylated CaMKII and NFATc3, revealing that TRPV3 might be a potential therapeutic target for cardiac hypertrophy. PMID: 30299584 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30299584?dopt=Abstract

Source: J Cell Mol Med - October 9, 2018 Category: Molecular Biology Authors: Zhang Q, Qi H, Cao Y, Shi P, Song C, Ba L, Chen Y, Gao J, Li S, Li B, Sun H Tags: J Cell Mol Med Source Type: research