Are Osteoporosis Drugs Linked With Survival? Debate Casts Doubt Are Osteoporosis Drugs Linked With Survival? Debate Casts Doubt

The mortality benefit of osteoporosis drugs is"probably around 10%," claims one expert. However, strong evidence to support prescribing these drugs for this reason"is just not there," says another.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

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Purpose of review Osteoporosis is a common public health problem that is often undertreated and underdiagnosed. The clinical management of osteoporosis is often reactionary to devastating fracture events. Bone turnover markers may improve the ease and rapidity at which osteoporosis is monitored and treated. Bone turnover markers are biochemical byproducts of bone formation or bone resorption. The clinical use of bone turnover markers is limited by significant preanalytical variability. Effective interpretation of bone turnover markers requires a detailed understanding of the variables that can affect their responses to o...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: PARATHYROIDS, BONE AND MINERAL METABOLISM: Edited by Vin Tangpricha Source Type: research
Abstract Ovarian dysgenesis, short stature, and infertility are common features of Turner syndrome (TS). Endocrinopathies and cardiopathies are less common, but may induce significant complications, and are the leading cause of mortality in TS patients. Endocrine abnormality including osteoporosis occurs in up to 60% of patients, hypothyroidism at an incidence of 3.2%, and impaired glucose metabolism with variable incidence depending on the age group. Estrogen therapy and growth hormone therapy, alone or combined, improve height and bone mass in TS patients. Autoimmune hypothyroidism is prone in the X-isochromosom...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia and osteoporosis is a condition in which bone density and quality become reduced. Both type 1 (TIDM) and type 2 diabetes mellitus (T2DM) are significantly linked with osteoporosis and fracture risk [1,2]. According to the International Diabetes Federation (IDF), DM is estimated to affect at least 425 million people worldwide, and this number will rise to 629 million by the year 2045 [3]. Osteoporosis leads to more than 8.9 million fractures annually, resulting in an osteoporotic fracture every 3 second worldwide [4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
DiscussionThis review will summarise the strength of the association between physical activity and selected chronic diseases and their markers among South Asian adults 40  years or older. The findings will provide an evidence base to guide public health policy and interventions in the South Asian region and to inform future research to address the rising burden of chronic diseases.Systematic review registrationPROSPEROCRD42018096505
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
AbstractObjectivesThe aim of this study is to investigate the effect of type 2 diabetes mellitus (T2DM) on the treatment outcomes of patients with postmenopausal osteoporosis (PMOP).Material and methodThirty-five patients who had been diagnosed as PMOP by lumbar and/or femoral neck bone mineral density screening (BMD) and who had comorbid T2DM were included in the study. Thirty-five patients who had been diagnosed as PMOP but who had no comorbidity including DM constituted the control group. Demographic features, biochemical parameters, femoral and lumbar T scores were all recorded. All patients were treated with bisphosph...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
This review provides an overview of the role of long-term treatment of severe asthma with oral corticosteroids (OCS) and its associated side-effects in adults. It is based on a systematic literature search conducted in MEDLINE, Embase and the Cochrane Library to identify relevant studies. After a short overview of severe asthma and its treatment we present studies showing a dose–response relationship in asthmatic patients treated with OCS and then consider by organ systems the undesired effects demonstrated in clinical and epidemiological studies in patients with OCS-dependent asthma. It was found that the risk of de...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Review Source Type: research
Authors: Singh P Abstract Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Bone diseases such as rickets in children, osteomalacia and osteoporosis in adults are related with vitamin D insufficiency. Literature evidences show t...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
CONCLUSIONS: The case studies taken into account for this review demonstrated that quite frequently both bone reabsorbing and bone deposition are impaired in pediatric diseases. Furthermore, for some of them, bone damage began in childhood but only manifested with age. The use of denosumab could represent a valid alternative therapeutic approach to improve bone health in children, although further studies need to be carried out. PMID: 30343446 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Tags: World J Pediatr Source Type: research
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy. Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. The...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 12 October 2018Source: The Lancet Diabetes &EndocrinologyAuthor(s): The Lancet Diabetes &Endocrinology
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
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