Are Osteoporosis Drugs Linked With Survival? Debate Casts Doubt Are Osteoporosis Drugs Linked With Survival? Debate Casts Doubt

The mortality benefit of osteoporosis drugs is"probably around 10%," claims one expert. However, strong evidence to support prescribing these drugs for this reason"is just not there," says another.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

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Authors: Aghaloo T, Pi-Anfruns J, Moshaverinia A, Sim D, Grogan T, Hadaya D Abstract Since their development, dental implants have become one of the most common procedures to rehabilitate patients with single missing teeth or fully edentulous jaws. As implants become more mainstream, determining the factors that affect osseointegration is extremely important. Medical risk factors identified to negatively affect osseointegration include diabetes and osteoporosis. However, other systemic conditions and medications that interfere with wound healing have not been as widely investigated. The aim of this systematic revie...
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
The U.S. Supreme Court on Monday threw out a lower court ruling that had revived hundreds of lawsuits accusing Merck&Co of failing to properly warn patients of debilitating thigh-bone fractures as a result of taking its osteoporosis drug Fosamax (alendronic acid).Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Diabetes & Endocrinology News Source Type: news
This study included 53 patients with diagnosed primary hyperparathyroidism and 30 healthy controls. Laboratory tests for the diagnosis of primary hyperparathyroidism and serum levels of CTRP3 measured for all patients. Bone mineral density was obtained on lumbar spine 1 and 4 by dual energy X-ray absorptiometry. Results Serum CTRP3 levels were lower in patients with primary hyperparathyroidism than in the control group (p
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
AbstractPurpose of ReviewAge and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the USA and the global increase in diabetes, efficacious, multi-dimensional therapies that can treat or prevent skeletal diseases associated with metabolic dysfunction and inflammatory disorders are acutely needed.Recent FindingsCa2+/calmodulin-dependent protein kinas...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
In this study, therefore, the underlying mechanism of methylglyoxal on osteoporosis was studied using both animal and cell models.In the animal model, rats were treated with either methylglyoxal or saline as control. In the cell model, the macrophage RAW264.7 was treated with methylglyoxal or vehicle control. Following the treatment, animal samples were harvested for micro-CT and real-time polymerase chain reaction analyses. Cell samples were harvested for MTT assay, RT-PCR, and Western Blotting analyses.In both animals and cell cultures, methylglyoxal was shown to induce osteoclastogenesis by increased gene expression of ...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 3 May 2019Source: Materials Science and Engineering: CAuthor(s): Sanjay Sharma, Ketan Hatware, Prashant Bhadane, Sainath Sindhikar, Dinesh K. MishraAbstractIn the twenty-first century, microneedles based drug delivery is drawing attention worldwide in the research due to current signs of progress in the controlled release drug delivery through microneedles. The microneedles represent a promising technology to deliver therapeutic compounds into the skin for chronic complications like osteoporosis, diabetes, cancer and induction of immune responses from protein and DNA vaccines. However, th...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, a rat model of diabetic osteoporosis was established by streptozotocin injection, the bone protective effects and potential mechanism of icariin on diabetes-induced bone loss was observed. Thirty 8-week-old female Sprague Dawley rats were divided into control group (vehicle treatment), T1DM (diabetic) group and T1DM-icariin (ICA) group (diabetic rats treated with icariin), 10 rats in each group. The bone histomorphometry parameters, bone mineral density (BMD), serum bone turnover markers, and bone marrow adipogenesis were analyzed after 8 weeks of icariin administration. The results showed consumption of ica...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Menopause is associated with an increasing risk to develop the so called metabolic syndrome. A major reason is the decrease of circulating estrogen, a sex steroid which is involved in a variety of metabolic processes. Estrogens affect fat metabolism, bone metabolism and protein metabolism. Declining estrogen levels are associated with adverse lipid profiles, a reduced ability o to metabolize fatty acids, reduced bone mass and density and with a decrease in skeletal muscle mass. All this has implications for the development of diseases like cardiovascular disease, sarcopenia, osteoporosis and diabetes type II.
Source: Maturitas - Category: Primary Care Authors: Tags: INV10 Source Type: research
ConclusionsCells in the hDPSC4s cell sheets survived for at least 96  h. Moreover, the cells in the cell sheets retained their stemness and their osteogenic differentiation potential.Clinical relevanceCell sheets of hDPSCs could be employed as natural tri-dimensional structures for treating bone loss. This technique would be useful particularly for critical bone defects or any type of bone defects in patients carrying diseases that impair bone regeneration, such as diabetes mellitus, medication-related osteonecrosis of the jaw (MRONJ), and osteoporosis.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Vertical sleeve gastrectomy (VSG) is an effective therapeutic approach for obesity and type 2 diabetes but is associated with osteoporosis. In this issue of the JCI, Li et al. report that VSG rapidly reduces bone mass, as observed in humans, via rapid demineralization and decreased bone formation, independent of weight loss or Ca2+/vitamin D deficiency. VSG also reduces bone marrow adipose tissue, in part via increased granulocyte–colony stimulating factor (G-CSF). The interplay between VSG-mediated effects on systemic metabolism and bone biology remain to be investigated. These findings suggest novel mechanisms and ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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