Molecules, Vol. 23, Pages 2601: Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

Molecules, Vol. 23, Pages 2601: Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity Molecules doi: 10.3390/molecules23102601 Authors: Violeta Rodriguez-Ruiz José Ángel Salatti-Dorado Abolfazl Barzegari Alba Nicolas-Boluda Amel Houaoui Carmen Caballo Noelia Caballero-Casero Dolores Sicilia Jorge Bastias Venegas Emmanuel Pauthe Yadollah Omidi Didier Letourneur Soledad Rubio Virginie Gueguen Graciela Pavon-Djavid Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin’s antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented. Their antioxidant activity was measured by α-Tocopherol Equivalent Antioxidant Capacity assay and was compared to those of both natural astaxanthin and α-tocopherol. Characterizations by dynamic light scattering, atomic force microscopy, and scattering electron microscopy techniques were carried out and showed spherical and surface negative charged particles with z-average and polydispersity...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research