Molecules, Vol. 23, Pages 2603: Correlation of Paraoxonase-1 with the Severity of Crohn ’s Disease

Molecules, Vol. 23, Pages 2603: Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease Molecules doi: 10.3390/molecules23102603 Authors: Katarzyna Szczeklik Tomasz Mach Dorota Cibor Danuta Owczarek Jacek Sapa Monika Papież Jolanta Pytko-Polończyk Wirginia Krzyściak Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed. Circulating PON-1 was found to be decreased in the CD group compared to the control group (269.89 vs. 402.56 U/L, respectively), and it correlated well with the disease activity. PON-1 correlated positively with hemoglobin (Hb) (r = 0.539, p < 0.001), hematocrit (Ht) (r = 0.48, p < 0.001), total cholesterol (TC) (r = 0.343, p < 0.001), high density lipoprotein (HDL) (r = 0.536, p < 0.001), low density lipoprotein (LDL) (r = 0.54, p < 0.001), and triglyceride (TG) (r = 0.561, p < 0.001)...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research