Molecules, Vol. 23, Pages 2603: Correlation of Paraoxonase-1 with the Severity of Crohn ’s Disease
Molecules, Vol. 23, Pages 2603: Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease
Molecules doi: 10.3390/molecules23102603
Authors:
Katarzyna Szczeklik
Tomasz Mach
Dorota Cibor
Danuta Owczarek
Jacek Sapa
Monika Papież
Jolanta Pytko-Polończyk
Wirginia Krzyściak
Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed. Circulating PON-1 was found to be decreased in the CD group compared to the control group (269.89 vs. 402.56 U/L, respectively), and it correlated well with the disease activity. PON-1 correlated positively with hemoglobin (Hb) (r = 0.539, p < 0.001), hematocrit (Ht) (r = 0.48, p < 0.001), total cholesterol (TC) (r = 0.343, p < 0.001), high density lipoprotein (HDL) (r = 0.536, p < 0.001), low density lipoprotein (LDL) (r = 0.54, p < 0.001), and triglyceride (TG) (r = 0.561, p < 0.001)...
Source: Molecules - Category: Chemistry Authors: Katarzyna Szczeklik Tomasz Mach Dorota Cibor Danuta Owczarek Jacek Sapa Monika Papie ż Jolanta Pytko-Polo ńczyk Wirginia Krzy ściak Tags: Article Source Type: research