Local recurrence of papillary thyroid cancer.

Local recurrence of papillary thyroid cancer. Expert Rev Endocrinol Metab. 2015 Jul;10(4):349-352 Authors: Sitges-Serra A Abstract Management of advanced papillary thyroid cancer (PTC>10 mm) is changing its focus. Mortality was the main outcome measure for patients treated before the 90s. In the past two decades, however, most patients diagnosed with PTC belong to the very low risk of death group. On the other hand, local recurrence of PTC remains a clinical problem, with rates up to 25% depending on the presence of nodal metastasis, tumor diameter, and the skill of the surgeon to completely remove the primary tumor and the associated lymph node metastasis at first-time thyroidectomy. After optimized surgery (total thyroidectomy plus central neck dissection), radioiodine ablation has very little influence on lymph node recurrence that now presents mostly as lateral neck node metastasis that was overlooked or incompletely resected at the time of initial surgery. PMID: 30293500 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

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Authors: Repaci A, Vicennati V, Paccapelo A, Cavicchi O, Salituro N, Monari F, de Biase D, Tallini G, Altimari A, Gruppioni E, Fiorentino M, Pagotto U Abstract Background: Stimulated thyroglobulin levels measured at the time of remnant ablation (A-hTg) and BRAFV600E mutation had shown prognostic value in predicting persistent disease in differentiated thyroid cancer (DTC). The aim of this study was to evaluate the prognostic role of A-hTg combined with the BRAFV600E status in association with the revised American Thyroid Association (ATA) risk stratification. Material and Methods: 620 patients treated for a DTC...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
In this study, we aimed to evaluate the prevalence and features of thyroid cancer in patients with toxic nodular goiter who underwent thyroidectomy.
Source: Surgery - Category: Surgery Authors: Source Type: research
This article explores the controversies over the extent of surgery for patients with very low-risk and low-risk differentiated thyroid cancer.
Source: Surgical Clinics of North America - Category: Surgery Authors: Source Type: research
CONCLUSION: The data documented the significance of re-stratifying pediatric patients with DTC on the basis of the findings obtained at the time of or after their initial therapy (total thyroidectomy and radioiodine ablation), predominantly in the intermediate/high-risk patients. In addition, DRS helped to better modulate the later follow-up, excluding a large number of intermediate/high risk patients from needless intensive workups, allowing personalization of follow-up management. PMID: 31060081 [PubMed - as supplied by publisher]
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Nuklearmedizin Source Type: research
Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related death. The prevalence of colorectal neoplasm is increasing. Many studies have shown that thyroid dysfunction may be connected with the higher risk of pancreatic and breast cancer, but only a few described the role of thyroid dysfunction and thyroid hormone (TH) replacement in the development and risk of CRC. The aim of this study is to summarise all findings and potentially elucidate the connection between TH imbalance and colorectal cancer. The systematic review was conducted according to PICO and PRISMA guidelines. We searched MEDLINE...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
In an attempt to prevent overly aggressive treatment of low-risk thyroid cancers, the American Thyroid Association changed guideline recommendations in late 2015 to state that either hemithyroidectomy or total thyroidectomy are acceptable operations for these patients. We hypothesized that surgeons would increasingly perform hemithyroidectomy after the release of these guidelines.
Source: Surgery - Category: Surgery Authors: Source Type: research
Yan Ding, Jun Feng, Xun-hua Xu, Jun Yao, Rong-Biao YingIndian Journal of Cancer 2019 56(2):173-175 A 41 year old man presented with a familial history of multiple endocrine neoplasia type 2A (MEN2A) and severe hypertension. Rearranged during transfection (RET) gene sequencing confirmed a Cys634Tyr mutation of TGC to TAC. Total thyroidectomy and bilateral neck dissection were performed and the pathological assessment revealed a medullary thyroid carcinoma (MTC), 0.6 cm in size on the right side (number of lymph nodes: 0/2, 0/15, 0/12, and 0/8 in areas VI, II, III, and IV, respectively) and a papillary thyroid carcinoma (PT...
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
This JAMA Insights Clinical Update reviews use of active ultrasonography surveillance of patients with thyroid cancer as a way to postpone or avoid thyroidectomy in patients with lower-risk tumors for whom surgery is more likely to be harmful than beneficial.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
The objective of this study was to evaluate the overall survival (OS) of 131I treatments alone and when combined with non-131I treatments in patients with bone metastases (BM) secondary to differentiated thyroid cancer (DTC). METHODS: This was a retrospective study of patients who were evaluated between 2001-2018 at MedStar Washington Hospital Center and had differentiated thyroid cancer (DTC), bone metastases (BM) and at least one 131I treatment after the diagnosis of BM. The OS was analyzed by Kaplan-Meier survival curves and was compared by log-rank test between two groups: patients who received 131I treatments alon...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusion: In this study, no correlation between EBV and thyroid diseases was found in a cohort from southern China. Introduction Epstein-Barr virus (EBV) is a well-known human tumor virus with a very high prevalence in the population, especially for children and youth. EBV serum (IgG) is positive in an estimated 95% of the world's population (1). EBV infection is associated with epithelial and lymphoid malignancies, including nasopharyngeal carcinoma (NPC), gastric cancer, Hodgkin's lymphoma and Burkitt's lymphoma (2, 3). Although EBV has B-lymphocyte tropism, it can also infect T lymphocy...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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