[The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes].

[The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes]. Pediatr Endocrinol Diabetes Metab. 2018;24(2):96-105 Authors: Wysoczańska-Klaczyńska A, Ślęzak A, Hetman M, Barg E Abstract Vitamin D activity is controlled by its receptor (VDR) located in many cells of the body. The presence of VDR in numerous cellular pathways suggests its important role in the etiology and development of many diseases. Increased risk of obesity, metabolic disturbances, bone mass disturbances and neoplasia among certain VDR alleles has been proven. The importance of VDR in the etiopathology of obesity is associated with the occurrence of polymorphisms: Fok1, Bsm1, Apa1, Taq1. VDR expression in adipocytes plays a role in the regulation of energy metabolism and the induction of obesity. Vitamin D and VDR polymorphisms can participate in the development of many metabolic disorders. The VDR gene is one of the better researched genes among patients with type 1 diabetes. The action of vitamin D affects the proper functioning and development of the skeletal system. Vitamin D has an effect on bone remodeling through its receptor and its polymorphisms: Apa1, Bsm1, Taq1, Fok1 and Cdx2. The identification and diagnosis of VDR varieties gives the possibility of early detection of the risk of osteoporosis or individual predisposition to its development. There is a high variability in the results of individual...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Tags: Pediatr Endocrinol Diabetes Metab Source Type: research