Physical activity: the key to cardiometabolic risk reduction in obstructive sleep apnoea

Obstructive sleep apnoea (OSA) is a prevalent sleep disorder, with recent estimates reporting prevalence ranging between 3% and 17% for moderate-severe OSA depending on age and sex [1].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research

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ConclusionThe use of dexmedetomidine and local anesthetic in pediatric tonsillectomy is a safe and effective protocol that allows for the reduction of opiate use and improved post-operative pain control.Key pointsQuestion: Can the combination of dexmedetomidine and infiltration of local anesthetic reduce overall opioid use for peediatric patients undergoing tonsillectomy?Findings: In this case-control study, use of dexmedetomidine and local anesthetic injected into the tonsillar fossa led to a decrease in intraoperative opiate use by 49.6%, a decrease in intraoperative sevofluorane use by 18%, and a lower reported maximum ...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Condition:   Obstructive Sleep Apnea Hypopnea Syndrome Intervention:   Sponsor:   University Hospital, Montpellier Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obstructive Sleep Apnea Interventions:   Drug: AD036 Dose 1;   Drug: AD036 Dose 2;   Drug: AD036 Dose 3;   Drug: Placebo Sponsor:   Apnimed Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obstructive Sleep Apnea Syndrome Interventions:   Device: Activated Inspire® Upper Airway Stimulation System;   Device: Inactivated Inspire® Upper Airway Stimulation System Sponsors:   University Hospital, Grenoble;   Inspire Medical Systems, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obstructive Sleep Apnea Intervention:   Device: transnasal high flow Sponsor:   Chung-Chieh, Yu Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obstructive Sleep Apnea Syndrome Interventions:   Device: Activated Inspire® Upper Airway Stimulation System;   Device: Inactivated Inspire® Upper Airway Stimulation System Sponsors:   University Hospital, Grenoble;   Inspire Medical Systems, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obstructive Sleep Apnea Intervention:   Device: transnasal high flow Sponsor:   Chung-Chieh, Yu Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, hypertension was modeled in rats by feeding a high salt diet (HSD) for 6 wk and exposuring to chronic intermittent hypoxia (CIH) during the sleep cycle. We found that OSA combined with HSD increased the severity of hypertension through increasing level of blood Trimethylamine-Oxide (TMAO), release of Th1-related cytokine (IFN-γ) and inhibition of anti-inflammatory cytokine (TGF-β1), and affected the gut microbiome in rats, particularly by depleting Lactobacillus. In addition, expression of PERK1/2, PAkt and PmTOR increased in the aorta from rats with a CIH exposure and HSD. Consequently, treatment...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
(American Academy of Sleep Medicine) A new clinical practice guideline from the American Academy of Sleep Medicine (AASM) provides guidance to clinicians on the use of positive airway pressure (PAP) therapy to treat obstructive sleep apnea (OSA) in adults.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
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