Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study

In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8–9-year follow-up study. We analysed data of 658 volunteers from the São Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20–80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile. Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296–0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252–0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(B)=0.720; p=0.001), interleukin-6 (exp(B)=0.991; p=0.03), insulin (exp(B)=0.982; p=0.03), triglycerides (exp(B)=0.997; p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Sleep apnoea Source Type: research

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Conclusions Aging leads to a progressive decrease in androgen production that, in turn, leads to the development of LOH, defined by significant low T serum levels (in the lowest quartile) in the presence of signs and symptoms of hypogonadism (51). LOH could be due to both testicular and hypothalamic-pituitary dysfunction (32), and ED is one of its main symptoms. ED in LOH is linked to increased oxidative stress, subclinical inflammation, and subsequent endothelial dysfunction (101). In elderly men, it has been shown that LOH is also linked to lower cAMP pool and to an alteration of the cGMP signaling pathway. PDE5 gene l...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract Obesity in pediatric population is an important global problem. The prevalence of obesity in children is dramatically rising. According to World Health Organization, about 41 million children under the age of 5 years are obese or overweight worldwide. Overweight and obesity are well-known risk factors for a number of health disorders. Diseases commonly observed in this group of patients are metabolic disorders, type 2 diabetes mellitus, cardiovascular diseases, fatty liver disease, musculoskeletal problems, and many others. The main aim of this study was to present the current knowledge of the association...
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Tags: Ear Nose Throat J Source Type: research
A 63-year-old man presented to the emergency department with 5 days of headache, chills, cough, and diffuse myalgias and 1 day of fever to a temperature of 39.9 °C. His history was significant for type 2 diabetes mellitus, coronary artery disease, hypertension, obstructive sleep apnea, and corticosteroid injection 2 months previously for chronic L4 discogenic radiculopathy. Three days before emergency department presentation he had contacted his primary ca re physician, who prescribed oseltamivir over the phone.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents' clinic Source Type: research
Type 2 diabetes mellitus (T2DM) is a metabolic disorder which mainly consists of altered glucose metabolism within the body and has a multi-factorial pathophysiology [1]. There are various metabolic and lifestyle risk factors which contribute to its development, of which lifestyle factors are considered to play a major role. Physical inactivity, obesity, smoking, alcohol consumption, and diet have led to an overt increase in the prevalence of diabetes in recent times [2,3]. Apart from these, impaired sleep has come out to be an important risk factor and predictor of T2DM and a growing body of evidence has indicated that sl...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
The relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and a variety of disease from obesity, type 2 diabetes mellitus and cardiovascular disease has been investigated previously. Reduced a...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
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Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
The Diabetes Sleep Treatment Trial (DSTT) is a multi-site, double-blinded, randomized, sham-controlled trial. The study objective is to test whether treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) treatment results in improved glycemic control and diabetes self-management behavior compared to participants on a sham-CPAP (sub-therapeutic) device in participants with type 2 diabetes mellitus (T2DM) and co-morbid OSA. The purpose of this paper is to describe the premise for the DSTT, the study design, and the methodology used in this on-going trial.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research
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Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
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Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
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Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
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