TCF4 promotes erythroid development

Transcription factor 4 (TCF4, ITF2, E2-2), is a basic helix-loop-helix (bHLH) transcription factor that belongs to the family of E-box binding proteins. These proteins recognize CANNTG (Ephrussi-box) DNA sequences, present in a variety of tissue-specific enhancers and promoters. E-proteins are widely expressed and can form both homodimers with other E-proteins or heterodimers with tissue specific bHLH proteins. Dimerization of bHLH transcription factors results in the formation of a four helix bundle, which allows the DNA binding domains to associate with the E-box recognition site, to regulate transcription [1].

Source: Experimental Hematology - October 10, 2018 Category: Hematology Authors: Florentien E.M. in 't Hout, Jolanda van Duren, Davide Monteferrario, Emma Brinkhuis, Niccolo Mariani, Theresia M. Westers, Dana Chitu, Gorica Nikoloski, Arjan A. van de Loosdrecht, Bert A. van der Reijden, Joop H. Jansen, Gerwin Huls Tags: Brief report Source Type: research