Chronic kidney disease: A model of impaired vascular remodeling

Chronic kidney disease (CKD) is a model of abnormal vascular remodeling associated with a dramatically increased risk of cardiovascular disease (CVD) [1]. In this issue of Atherosclerosis, Matsushita [2] and coworkers expand our knowledge by showing in a large, prospective epidemiological study a graded and independent association of renal function at study inception with the risk of developing abdominal aorta aneurism (AAA) at follow-up [2]. Compared to individuals with normal renal function [estimated glomerular filtration rate – (eGFR) > 90 ml/min/1,73 m2], a significant 4.40 [95% Confidence Interval (95%CI): 1.58–12.49], 3.29 (95%CI: 1.89–5.72), 2.03 (95%CI: 1.29–3.03), 1.62 (95%CI: 1.11–2.35) fold increase in the risk of developing AAA was noted among subjects with CKD stage 4 (eGFR
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Editorial Source Type: research

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Abstract OBJECTIVE: To report the spectrum of ethambutol induced optic neuropathy in a group of renal patients with tuberculosis and the role of visual evoked response (VER) in evaluating this disorder. METHODS: Twenty-three renal patients who were started on ethambutol as a part of anti-tubercular treatment for tuberculosis in India, were divided into 4 groups based on glomerular filtration rate (GFR): group 1-chronic kidney disease (CKD) with GFR 30 ≤ 60 mL/min; and group 4-GFR> 60
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Conclusions: Enarodustat corrected and maintained Hb levels in anemic patients with hemodialysis-dependent CKD. Phase 3 studies of enarodustat are currently ongoing.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
ConclusionsThese two observations suggest that voiding cystourethrography (VCUG) should be carefully considered in newborns with severe uropathy, particularly in the case of renal insufficiency. If indicated, thyroid function should be monitored in the following weeks, and in case of hypothyroidism treatment should be started.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study investigated the impact of body composition in the arterial stiffness of children with chronic kidney disease (CKD).MethodsFat mass (FM), fat tissue index (FTI), fat-free mass (FFM), fat-free tissue index (FFTI), and FFTI/FTI were measured in 26 patients and 25 healthy controls by bio-impedance analysis. Data on patient ’s body mass index (BMI) for height-age, serum albumin, glomerular filtration rate (GFR), blood pressure status, and pulse wave velocity (PWV) were collected in patients.ResultsPatients presented lower levels of FM and FFM compared to healthy controls (p = 0.04 andp =&t...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundSpina bifida (SB) patients are at increased risk for hydronephrosis, bladder storage and emptying problems, and renal failure that may require multiple bladder surgeries.MethodsWe retrospectively reviewed patients born with SB 2005 –2009, presenting to our institution within 1 year of birth. Outcomes at 8–11 years old included final renal/bladder ultrasound (RBUS) results, clean intermittent catheterization (CIC) use, anticholinergic use, surgical interventions, and final renal function. We excluded those without follow- up past age 8 and/or no RBUS or fluoroscopic urodynamic images ...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conditions:   Renal Insufficiency, Chronic;   Heart Failure With Preserved Ejection Fraction Interventions:   Dietary Supplement: MitoQ;   Dietary Supplement: Placebo Sponsor:   Virginia Commonwealth University Recruiting
Source: - Category: Research Source Type: clinical trials
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Publication date: Available online 22 May 2019Source: American Heart JournalAuthor(s): Alexander R. Opotowsky, Matthew Carazo, Michael N. Singh, Konstantinos Dimopoulos, David A. Cardona-Estrada, Ahmed Elantably, Sushrut S. Waikar, Finnian R. Mc Causland, Gruschen Veldtman, Jasmine Grewal, Catherine Gray, Brittani N. Loukas, Saurabh RajpalAbstractBackgroundGlomerular filtration rate is a key physiologic variable with a central role in clinical decision-making and a strong association with prognosis in diverse populations. Reduced estimated glomerular filtration rate (eGFR) is common among adults with congenital heart disea...
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Marie Patrice H, Joiven N, Hermine F, Jean Yves B, Folefack François K, Enow Gloria A Abstract BACKGROUND: Late presentation (LP) of chronic kidney disease (CKD) patients to nephrologist is a serious problem worldwide with persistent high prevalence despite known benefits of early nephrology care. OBJECTIVE: Determine the prevalence and factors associated with LP of CKD patients to nephrologists in Cameroon. METHODS: A cross-sectional study from October 2015 to May 2016 at the nephrology units of the Douala General and Laquintinie hospitals, including all consenting incident CKD patients. Da...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Authors: Liu Y, Wu Y, Diao Z, Guo W, Liu W Abstract BACKGROUND: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there is an urgent need to identify therapeutic targets to control the progression of cardiovascular disease. Apoptosis of aortic smooth muscle cells can promote cardiovascular disease, but the role of parathyroid hormone (PTH) and sirtuin 1 in the pathophysiology of apoptosis is still unclear. METHODS: Cultured human aortic smooth muscle cells (HASMCs) were stimulated with 10-6, 10-8, or 10-10 mol/L PTH for different days, apoptosis was measured b...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
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