Chronic kidney disease: A model of impaired vascular remodeling

Chronic kidney disease (CKD) is a model of abnormal vascular remodeling associated with a dramatically increased risk of cardiovascular disease (CVD) [1]. In this issue of Atherosclerosis, Matsushita [2] and coworkers expand our knowledge by showing in a large, prospective epidemiological study a graded and independent association of renal function at study inception with the risk of developing abdominal aorta aneurism (AAA) at follow-up [2]. Compared to individuals with normal renal function [estimated glomerular filtration rate – (eGFR) > 90 ml/min/1,73 m2], a significant 4.40 [95% Confidence Interval (95%CI): 1.58–12.49], 3.29 (95%CI: 1.89–5.72), 2.03 (95%CI: 1.29–3.03), 1.62 (95%CI: 1.11–2.35) fold increase in the risk of developing AAA was noted among subjects with CKD stage 4 (eGFR
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Editorial Source Type: research