Visible-Light-Driven, Copper-Catalyzed Decarboxylative C(sp3)-H Alkylation of Glycine and Peptides.

Visible-Light-Driven, Copper-Catalyzed Decarboxylative C(sp3)-H Alkylation of Glycine and Peptides.
Angew Chem Int Ed Engl. 2018 Oct 08;:
Authors: Wang C, Guo M, Qi R, Shang Q, Liu Q, Wang S, Zhao L, Wang R, Xu Z
Abstract
Despite a well-developed and growing body of work in Cu catalysis, the potential of Cu to serve as a photocatalyst remains underexplored. We here report the first example of visible-light-induced Cu-catalyzed decarboxylative C(sp3)-H alkylation of glycine for preparing α-alkylated unnatural α-amino acids. It merits mentioning that the mild conditions and the good functional group tolerance allow the modification of peptides using this method. The mechanistic studies revealed that a radical-radical coupling pathway was involved in the reaction.
PMID: 30296349 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - October 8, 2018 Category: Chemistry Authors: Wang C, Guo M, Qi R, Shang Q, Liu Q, Wang S, Zhao L, Wang R, Xu Z Tags: Angew Chem Int Ed Engl Source Type: research