FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models [Neuroscience]

FUS (fused in sarcoma) proteinopathy is a group of neurodegenerative diseases characterized by the formation of inclusion bodies containing the FUS protein, including frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Previous studies show that mitochondrial damage is an important aspect of FUS proteinopathy. However, the molecular mechanisms by which FUS...

Source: Proceedings of the National Academy of Sciences - October 9, 2018 Category: Science Authors: Jianwen Deng, Peng Wang, Xiaoping Chen, Haipeng Cheng, Jianghong Liu, Kazuo Fushimi, Li Zhu, Jane Y. Wu Tags: PNAS Plus Source Type: research