Jury Still Out on Statins' Benefit Beyond the Heart

(MedPage Today) -- Review finds suggestive evidence insufficient to move practice
Source: MedPage Today Pulmonary - Category: Respiratory Medicine Source Type: news

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AbstractPurpose of ReviewThis paper provides a concise update on the management of peripheral artery disease (PAD).Recent FindingsPAD continues to denote a population at high risk for mortality but represents a threat for limb loss only when associated with foot ulcers, gangrene, or infections. Performing either angiogram or non-invasive testing for all patients with foot ulcers, gangrene, or foot infections will help increase the detection of PAD, and refined revascularization strategies may help optimize wound healing in this patient group. Structured exercise programs are becoming available to more patients with claudic...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Researchers at the University of Toronto found elderly people who received the drug after a hit to the head were 13 percent less likely to develop dementia then those who didn't.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Interview with Donald A. Redelmeier, MD, FRCPC, MSHSR, FACP, author of Association Between Statin Use and Risk of Dementia After a Concussion
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts
MONDAY, May 20, 2019 -- More than one-third of patients on statin therapy fail to achieve therapeutic thresholds for low-density lipoprotein cholesterol (LDL-C), according to a study published in the May issue of the Journal of Managed Care&...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(JAMA Network) Concussion is a common brain injury. This observational study of nearly 29,000 adults (66 and older) diagnosed with concussion examined whether statin use was associated with risk of long-term dementia after a concussion.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
This large extended population-based double cohort study tests whether statin use is associated with an increased or decreased risk of subsequent dementia after a concussion among older adults.
Source: JAMA Neurology - Category: Neurology Source Type: research
Traumatic brain injury (TBI) is a major cause of death and disability in the United States, where 1.4 million people sustain a TBI annually and 3 to 5 million are currently living with a TBI-associated disability. Concussions are a common component of TBI. Severe TBI, such as events that involve a loss of consciousness, has received a lot of attention; it is known that athletes who experience a high rate of these events have an increased risk of chronic traumatic encephalopathy. What is less known is the short-term and long-term effects of events that do not involve a loss of consciousness. One of the most feared long-term...
Source: JAMA Neurology - Category: Neurology Source Type: research
AbstractPurpose of ReviewHypercholesterolemia and statin treatment are nowadays common among people older than 75  years, but clinical heterogeneity in this increasing age group is wide, and treatment decisions may differ from those in younger patients. Aim is to discuss the presentation, modifying factors, and treatment decisions of hypercholesterolemia (usually with statins) in older persons and focusing on primary prevention.Recent FindingsThere are no randomized controlled trials in persons older than 80  years at baseline. Randomized controlled trial findings in younger patients and 75+ subgroups and in obse...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity, insulin resistance (IR) and the metabolic syndrome (MetS) and is a leading cause of cirrhosis [1,2]. Its global prevalence is 25% [3] and is increasing worldwide [4] accompanied by severe complications particularly in high-risk older obese patients [5]. Thiazolidinediones, statins and vitamin E have been proposed for the management of NAFLD [6,7] together with lifestyle modifications [8], but there is currently no specifically approved medication.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 18 May 2019Source: PeptidesAuthor(s): Allison B. Reiss, Daniel S. Glass, Eric Lam, Amy D. Glass, Joshua De Leon, Lora J. KasselmanAbstractCardiovascular disease (CVD) remains the leading cause of death worldwide, despite multiple treatment options. In addition to elevated lipid levels, oxidative stress and inflammation are key factors driving atherogenesis and CVD. New strategies are required to mitigate risk and most urgently for statin-intolerant patients. The neuropeptide hormone oxytocin, synthesized in the brain hypothalamus, is worthy of consideration as a CVD ancillary treatment be...
Source: Peptides - Category: Biochemistry Source Type: research
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