Jury Still Out on Statins' Benefit Beyond the Heart

(MedPage Today) -- Review finds suggestive evidence insufficient to move practice
Source: MedPage Today Pulmonary - Category: Respiratory Medicine Source Type: news

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Abstract Cardiovascular risk management in human immunodeficiency virus (HIV)-infected individuals is gaining increased attention due to the rising incidence and prevalence of cardiovascular disease in this population. Despite the availability of efficacious treatment strategies, implementation of guideline advocated preventive therapy, such as lipid-lowering therapy with statins, is hampered by perceived, expected, and real side effects as well as by expected interactions with combination antiretroviral therapy. These obstacles to optimal treatment have resulted in a large gap between the number of patients in wh...
Source: AIDS Reviews - Category: Infectious Diseases Authors: Tags: AIDS Rev Source Type: research
This study aimed to investigate the antitumor effect of fluvastatin on lung cancer and its possible mechanics.Main methodsCell viability assay was used to examine the inhibition of fluvastatin on proliferation of H292 cells. In order to investigate the antitumor mechanics, SATB1 knock-down H292 cells was constructed by lentiviral transfection. RT-PCR and Western blot were performed to examine the effects of fluvastatin on expression of SATB1 and Wnt/β-catenin signaling components.Key findingsFluvastatin significantly inhibited proliferation and invasion of H292 cells in a time- and dose-dependent manner and promoted the apoptosis (p 
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsPresent findings demonstrate that only lipid-soluble among tested statins were effective in inhibition of growth and invasiveness of HES cells. These findings may have clinical relevance in treatment of endometriosis.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Carotid stents, more stem-cell retractions, AHA statement on statin safety, flu vaccine rules, medication errors, veterans care, and wasteful NIH research on golfing are discussed in this week ’ s podcast.theheart.org on Medscape
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Commentary Source Type: news
ConclusionsOur results suggest that metformin users are more likely to initiate preventive therapies and engage in other healthy behaviors. Failure to account for these behaviours may introduce healthy user bias into studies evaluating the effect of oral antidiabetic therapies.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
This study aimed to elucidate the impact of OATP1B1 genotype (*1b/*1b, *1b/*15, and *15/*15) on plasma concentrations of endogenous OATP1B1 substrates. Healthy volunteers with OATP1B1 *1b/*1b (n = 10), *1b/*15 (n = 7), or *15/*15 (n = 2) received oral administration of a cocktail of statins (atorvastatin, pitavastatin, rosuvastatin, and fluvastatin). Mean area under the plasma concentration of atorvastatin, pitavastatin, and rosuvastatin in OATP1B1 *15/*15 were 2.2, 1.7 and 1.58-times greater than the corresponding values in OATP1B1 *1b/*1b, respectively, whereas that of fluvastatin was identi...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
The benefits of statins outweigh the harms, the report asserts, which is likely to renew calls for the release of patient-level data from industry-sponsored statin trials for independent scrutiny.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news
Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins.Resumo Fundamentos: Crian ças com hipercolesterolemia familiar podem desenvolver dano endotelial precoce, aumentando o risco de desenvolver doenças cardiovasculares. As estatinas tiveram sua eficácia em diminuir níveis de colesterol LDL e eventos cardiovasculares em adultos comprovada. O efeito das estatinas na populaçã o pediátrica não está claramente demonstrado. Objet...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins.Resumo Fundamentos: Crian ças com hipercolesterolemia familiar podem desenvolver dano endotelial precoce, aumentando o risco de desenvolver doenças cardiovasculares. As estatinas tiveram sua eficácia em diminuir níveis de colesterol LDL e eventos cardiovasculares em adultos comprovada. O efeito das estatinas na populaçã o pediátrica não está claramente demonstrado. Objet...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
AbstractCoronary heart disease (CHD) is the leading cause of mortality worldwide and high low-density lipoprotein (LDL) cholesterol levels have been shown to be key in the pathogenesis of this condition. Lipid control has therefore been the subject of decades of research and has led to many large and robust randomized controlled trials, as well as the highest grossing drug of all time —Lipitor (atorvastatin). Statin therapy has long been indicated for secondary and more recently primary prevention. However, despite the large-scale use of statins, CHD prevalence remains high, and some patients do not respond to statin...
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
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