Crystallization, room-temperature X-ray diffraction and preliminary analysis of Kaposi's sarcoma herpesvirus LANA bound to DNA

This report describes the rational protein engineering for successful co-crystallization with DNA and X-ray diffraction data collection at room temperature on the high-brilliance third-generation synchrotron PETRA III at DESY, Germany.
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: Kaposi's sarcoma herpesvirus structure-guided mutagenesis latency-associated nuclear antigen laboratory communications Source Type: research

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Conclusions: Treatment outcome of PRCA depended upon the causes and the types of treatment, and the burden of RBC transfusion was very high in patients with ESA and thymoma-associated PRCA. PMID: 32257434 [PubMed]
Source: Anemia - Category: Hematology Tags: Anemia Source Type: research
Publication date: Available online 8 April 2020Source: Urology Case ReportsAuthor(s): Zachary M. Kozel, Jennifer E. Reifsnyder, Luke Griffiths, Jordan S. Gitlin, Louis R. Kavoussi
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conclusions: While demographic and clinical characteristics were similar, treatment patterns changed in 2016. Future research should evaluate the impact of changing drug approvals and clinical trial results on future treatment patterns. PMID: 32256184 [PubMed - as supplied by publisher]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
The distinction between a uterine endometrial stromal nodule (ESN) and low-grade endometrial stromal sarcoma (LGESS) is based on the nature of the interface between the lesion and the surrounding myometrium and the presence or absence of vascular invasion. Most LGESS exhibit widespread irregular myometrial invasion with or without vascular invasion, whereas ESNs are well-circumscribed without vascular invasion. Tavassoli and Norris proposed that minor marginal irregularity (up to 3 protrusions, each
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: ORIGINAL ARTICLES Source Type: research
This study presents evidence that the ectopic expression of SIRT1 attenuates RAS- or MEK-driven ERK activation and reduces cellular proliferation and transformation in vitro. The attenuation of ERK activation by SIRT1 results from prompt dephosphorylation of ERK, while MEK activity remains unchanged. We identified that MKP1, a dual specific phosphatase for MAPK, was deacetylated by SIRT1. Deacetylation of MKP1 by direct interaction with SIRT1 increased the binding affinity to ERK which in turn facilitated inactivation of ERK. Taken together, these results suggest that SIRT1 would act as a tumor suppressor by modulating RAS...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Tugba Keskin, Arnaud Bakaric, Patricia Waszyk, Gaylor Boulay, Matteo Torsello, Sandrine Cornaz-Buros, Nadja Chevalier, Thibaud Geiser, Patricia Martin, Angela Volorio, Sowmya Iyer, Anupriya Kulkarni, Igor Letovanec, Stéphane Cherix, Gregory M. Cote, Edwin Choy, Antonia Digklia, Michael Montemurro, Ivan Chebib, Petur G. Nielsen
Source: Cell Reports - Category: Cytology Source Type: research
Conditions:   Solid Tumors;   Neuroblastoma;   Rhabdomyosarcoma;   Ewing Sarcoma;   Hepatoblastoma;   Medulloblastoma Interventions:   Drug: VAL-413;   Drug: Temozolomide Sponsor:   Valent Technologies, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Soft-tissue sarcomas represent a heterogeneous group of diseases with distinct genetic and clinical features accounting for up to 1% of cancer in adults and 15% of cancer in children. Epithelioid sarcoma is an...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Editorial Source Type: research
This randomized trial compares the effect of doxorubicin plus olaratumab vs doxorubicin plus placebo on overall survival in patients with advanced/metastatic soft tissue sarcoma and leiomyosarcoma.
Source: JAMA - Category: General Medicine Source Type: research
More News: Biochemistry | Laboratory Medicine | Mergers and Aquisitions | Sarcomas