Anti-NMDA receptor encephalitis presenting as isolated aphasia in an adult.

We report a case of an adult patient with anti-NMDA-r encephalitis presenting with isolated, abrupt-onset aphasia. Her condition remained unaltered over a period of 6 months. The patients' electroencephalogram findings were typical for NMDA-r encephalitis; however, her magnetic resonance imaging and cerebrospinal fluid analysis were normal. She responded well to immunotherapy, and aphasia eventually resolved. The natural course of the present case contradicts the rapidly progressive nature of typical NMDA-r encephalitis. Furthermore, it broadens the clinical spectrum of anti-NMDA-r encephalitis, to incorporate isolated, nonprogressive aphasia. PMID: 30293488 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30293488?dopt=Abstract

Source: Neurocase - October 6, 2018 Category: Neurology Authors: Constantinides VC, Kasselimis DS, Paraskevas GP, Zacharopoulou M, Andreadou E, Evangelopoulos ME, Kapaki E, Kilidireas C, Stamboulis E, Potagas C Tags: Neurocase Source Type: research