Prediction of long-term renal denervation efficacy

Publication date: Available online 9 October 2018Source: Cor et VasaAuthor(s): Jan Kvasnička, Lukáš Lambert, Petr Waldauf, Tomáš Zelinka, Ondřej Petrák, Branislav Štrauch, Robert Holaj, Tomáš Indra, Zuzana Krátká, Judita Klímová, Jan Václavík, Eva Kociánová, Igor Nykl, Otakar Jiravský, Gabriela Rappová, Miloš Táborský, Marian Branny, Jiří Widimský, Ján RosaAbstractDiversity of blood pressure response and great variability within studies emphasise the need to identify predictors of renal denervation efficacy. Previous studies identified various predictors within periods of 3–6 months. The goal of the current study is to examine the possible predictors of sustained decline of blood pressure (BP) after renal denervation in a long-term period of 2 years.Evaluated patients were either randomised in the original Prague-15 study or were pilot patients, meeting the same inclusion criteria of true-resistant hypertension. Patients were considered as responsive when the decline of 24 h systolic BP ≥ 10 mmHg was present 6, 12 and 24 months after the procedure. In addition, analysis for separate visits was performed. Denervation was performed using the unipolar Symplicity® Renal Denervation System. Extensive assessment of computed tomography angiography by numerous measurements including morphology of the renal arteries was performed.A total of 48 patients were analysed, with 27 patients suitable for long-term prediction. Five of the 27 ...
Source: Cor et Vasa - Category: Cardiology Source Type: research