Prognostic value of pre- and post-operative circulating tumor cells detection in colorectal cancer patients treated with curative resection: a prospective cohort study based on ISET device

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 21 September 2019Source: Enzyme and Microbial TechnologyAuthor(s): Ashraf S.A. El-Sayed, Ahmed A. Shindia, Azza A. Abou Zeid, Amany M. Yassin, Mahmoud Z. Sitohy, Basel SitohyAbstractThe potential anticancer activity of arginine deiminase (ADI) via deimination of L-arginine into citrulline has been extensively verified against various arginine-auxotrophic tumors, however, the higher antigenicity, structural instability and in vivo proteolysis are the major challenges that limit this enzyme from further clinical implementation. Since, this clinically applied enzyme was derived from Mycobact...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
British Journal of Cancer, Published online: 23 September 2019; doi:10.1038/s41416-019-0579-2Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: December 2019Source: Biomedicine &Pharmacotherapy, Volume 120Author(s): Peiqi Xu, Kai Yin, Xinyi Tang, Jie Tian, Yue Zhang, Jie Ma, Huaxi Xu, Qinglei Xu, Shengjun WangAbstractMetformin, an oral medicine broadly used for the treatment of type 2 diabetes, has been found to significantly improve tumor incidence and survival in large-scale clinical analysis. In recent years, the antitumor effect and mechanism of metformin have received much attention. Myeloid-derived suppressor cells (MDSCs), a major immunosuppressive cell type that accumulates in tumor-bearing hosts, can inhibit T cells and promote tumor...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In my urban primary care clinic, creativity and advocacy are some of our most basic tools. Recently, one of our residents brought up a homeless patient ’s social barriers to colorectal cancer screening: no companion to escort her home from a colonoscopy, no address to send a mail-in test, no reliable commode location to collect a […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Public Health & Policy Source Type: blogs
Publication date: December 2019Source: Journal of Functional Foods, Volume 63Author(s): Diego Ballesteros-Vivas, Gerardo Alvarez-Rivera, Carlos León, Sandra Johanna Morantes, Elena Ibánez, Fabián Parada-Alfonso, Alejandro Cifuentes, Alberto ValdésAbstractA comprehensive Foodomics study was carried out in this work to investigate the changes induced at gene and metabolite expression levels on HT29 colon cancer cell lines upon treatment with a bioactives-enriched extract from goldenberry calyx. As a result of the proposed multi-omics approach, the tested extract induced transcriptional activation ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study aimed to determine the survival effect of TB and TSR in elderly stage I CC patients.MethodsWe evaluated these parameters in eighty-eight stage I CC patients who underwent surgical treatment alone between 1998 and 2015. The relationship between these parameters and age was investigated. Model A was used for methodology.ResultsIn elderly patients (≥68), these parameters obtained more successful results for following analysis: relationship between prognostic factors [lymphatic invasion (BD, p = 0.003; TSR, p = 0.003), perineural invasion (BD, p = 0.016; TSR, p =&t...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
A new study from the University of South Australia researchers found the number of people that die from bowel or colorectal cancer (CRC) would be much higher without pre-diagnostic colonoscopies. Now more than 700,000 people die from bowel cancer each year according to the university. The researchers from the University’s Cancer Epidemiology and Population Health looked at data from 12,906 bowel cancer patients that indicate the fecal occult blood testing (FOBT) with a follow-up colonoscopy plays a key role in catching the disease early before symptoms appear. Results show that having one pre-diagnostic c...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Purpose: Older adults with cancer experience more toxicity from anticancer therapy, possibly because of age-related changes in the pharmacokinetic (PK) profile of anticancer drugs. We aimed to evaluate studies investigating the effect of aging on the PK of anticancer therapies used in the treatment of colorectal cancer (CRC). Methods: A systematic literature search of EMBASE and PubMed was performed to find eligible studies that assessed the effect of age on the PK of anticancer therapies used in the treatment of CRC. Results: The 21 eligible studies included 17 prospective studies and 4 pooled analyses of prospect...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Focus Series: TDM in Oncology Source Type: research
Source: Journal of Computational and Theoretical Nanoscience - Category: Nanotechnology Authors: Tags: research-article Source Type: research
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