CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

How new T  cell responses are mounted during chronic infection is unclear. Snell et al. demonstrate that unlike T cells primed at the onset of infection, CD8+ T cells primed after chronic viral infection is established are differentially programmed into less exhausted, TCF1+ memory-like cells that respond better to immunotherapy but diminish immunity to cancers that arise in chronic infection.

Source: Immunity - October 9, 2018 Category: Allergy & Immunology Authors: Laura M. Snell, Bethany L. MacLeod, Jaclyn C. Law, Ivan Osokine, Heidi J. Elsaesser, Kebria Hezaveh, Russell J. Dickson, Marc A. Gavin, Cynthia J. Guidos, Tracy L. McGaha, David G. Brooks Tags: Article Source Type: research