Implications of human induced pluripotent stem cells in metabolic disorders: from drug discovery toward precision medicine.

Implications of human induced pluripotent stem cells in metabolic disorders: from drug discovery toward precision medicine.
Drug Discov Today. 2018 Oct 04;:
Authors: Cota-Coronado A, Ramírez-Rodríguez PB, Padilla-Camberos E, Diaz NF, Flores-Fernández JM, Avila-Gonzalez D, Diaz-Martinez NE
Abstract
Human induced pluripotent stem cells (hiPSCs) enable in vitro high-throughput pharmacological screening assays of diseased tissue. Together with recent genome-wide association studies (GWAS), hiPSCs enable the identification of key mutations for the development of effective treatments based on precise drugs. In concert with CRISPR/Cas9 systems, hiPSC technology can reveal therapeutic targets in metabolic disorders. The ex vivo CRISPR correction of autologous patient-derived hiPSCs has led to the development of replacement cell therapies, providing better patient prognoses.
PMID: 30292915 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - October 4, 2018 Category: Drugs & Pharmacology Authors: Cota-Coronado A, Ramírez-Rodríguez PB, Padilla-Camberos E, Diaz NF, Flores-Fernández JM, Avila-Gonzalez D, Diaz-Martinez NE Tags: Drug Discov Today Source Type: research