TR α inhibits arterial renin-angiotensin system expression and prevents cholesterol accumulation in vascular smooth muscle cells.
CONCLUSION: TRα seems to have an inhibitory impact on AGTand AT1Raexpression, and loss of TRα function in TRα0/0 mice increases tRAS expression in the aortic wall. More importantly, TRα deletion significantly increases VSMC cholesterol content. Our results are consistent with a protective role of TRα against atherosclerosis.
PMID: 30292450 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - Category: Endocrinology Authors: Neggazi S, Hamlat N, Canaple L, Gauthier K, Samarut J, Bricca G, Aouichat-Bouguerra S, Beylot M Tags: Ann Endocrinol (Paris) Source Type: research