Multilayered heterogeneity as an intrinsic hallmark of neuroendocrine tumors.

Multilayered heterogeneity as an intrinsic hallmark of neuroendocrine tumors.
Rev Endocr Metab Disord. 2018 Oct 06;:
Authors: Pedraza-Arévalo S, Gahete MD, Alors-Pérez E, Luque RM, Castaño JP
Abstract
Neuroendocrine tumors (NETs) comprise a complex and highly heterogeneous group of neoplasms that can arise all over the body, originating from neuroendocrine cells. NETs are characterized by a general lack of symptoms until they are in advanced phase, and early biomarkers are not as available and useful as required. Heterogeneity is an intrinsic, pivotal feature of NETs that derives from diverse causes and ultimately shapes tumor fate. The different layers that conform NET heterogeneity include a wide range of distinct characteristics, from the mere location of the tumor to its clinical and functional features, and from its cellular properties, to the core signaling and (epi)genetic components defining the molecular signature of the tumor. The importance of this heterogeneity resides in that it translates into a high variability among tumors and, hence, patients, which hinders a more precise diagnosis and prognosis and more efficacious treatment of these diseases. In this review, we highlight the significance of this heterogeneity as an intrinsic hallmark of NETs, its repercussion on clinical approaches and tumor management, and some of the possible factors associated to such heterogeneity, including epigenetic and genetic elements, ...

Source: ENDOCR REV - October 6, 2018 Category: Endocrinology Authors: Pedraza-Arévalo S, Gahete MD, Alors-Pérez E, Luque RM, Castaño JP Tags: Rev Endocr Metab Disord Source Type: research