Carriers of cystic fibrosis may be at greater risk for allergic bronchopulmonary aspergillosis
Carriers of cystic fibrosis may be at greater risk for allergic bronchopulmonary aspergillosisTue, 10/09/2018 - 11:45News blog
CONCLUSION: The use of multiple recombinant antigens may improve the diagnostic accuracy in CF complicated with ABPA or AB. Asp f1 reactivity may relate to the presence of actively growing Aspergillus spp., which might be a useful marker for guiding antifungal therapy in ABPA. PMID: 31090534 [PubMed - as supplied by publisher]
Aspergillus is the causative agent of human diseases ranging from asthma to invasive infection. Genetic and environmental factors are crucial in regulating the interaction between the host and Aspergillus. The role played by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which catalyzes the first and rate-limiting step of tryptophan catabolism along the kynurenine pathway, is increasingly being recognized, but whether and how genetic variation of IDO1 influences the risk of aspergillosis in susceptible patients is incompletely understood. In addition, whether the closely related protein IDO2 plays a similar role remains ...
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Allergic bronchopulmonary aspergillosis is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus. This disorder is most commonly seen in patients with poorly controlled asthma and cystic fibrosis. It is rarely reported in chronic granulomatous disease patients; however, there are no cases reported with hematopoietic stem cell transplantation in the English literature. Herein, we report a patient with chronic granulomatous disease who had hematopoietic stem cell transplantation and subsequently developed allergic bronchopulmonary aspergillosis.
Conditions: Aspergillosis; Cystic Fibrosis Intervention: Drug: PC945 Sponsor: Pulmocide Ltd Not yet recruiting
Publication date: Available online 16 February 2019Source: Journal de Mycologie MédicaleAuthor(s): M. Hassanzad, V. Mortezaee, F. Bongomin, M. Poorabdollah, S. Sharifynia, M. Maleki, N. Hedayati, A.A. Velayati, M.T. HedayatiAbstractA 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was 8 years old and he had been treated with several course of oral glucocorticoids for recurrent exacerbations. He was readmitted when aged 12 with a history of worsening shortness of breath and c...
Azole-resistant Aspergillus fumigatus (ARAF) has been reported in the domestic environment of patients at risk for aspergillosis. Here, we assessed the mother's and father's homes of an 18-year-old cystic fibrosis patient harbouring chronic colonisation with H285Y CYP51A azole-resistant isolate, in order to explore the link between environmental exposure and ARAF infection. In one dwelling, a very high overall contamination level was found (710 –7.240 CFU/m3), with a predominance of A. fumigatus (640–6.490 CFU/m3), and ARAF showing the TR34/L98H mutation was isolated.
In conclusion, a non-negligible proportion of patients with nonspecific alterations of screening tests at baseline may develop Aspergillus-associated syndromes during follow-up. Future studies are needed to confirm our observations.
Conclusion: Aspergillus categorizations using recommended definitions could not be confirmed in all patients. Using asp-specific T cell responses expand the aspergillus categories and enables to distinguish between allergic and infectious disease.