A fatal and deceiving case of copper sulphate poisoning

Divya Gupta, Sukhyanti Kerai, Mohd S BudooIndian Journal of Anaesthesia 2018 62(10):819-820
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research

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In this study we used HPLC and LC/MS analysis, combined with a BATMAN-TCM platform, for detailed HPLC fingerprint analysis and network pharmacology of QP, and investigated the anti-inflammatory and antipruritic activities of QP on ACD induced by squaric acid dibutylester (SADBE) in mice. The BATMAN-TCM analysis provided information of effector molecules of the main ingredients of QP, and possible chronic dermatitis-associated molecules and cell signaling pathways by QP. In ACD mice, QP treatment suppressed the scratching behavior induced by SADBE in a dose-dependent manner and inhibited the production of Th1/2 cytokines in...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Summary Acquired methaemoglobinaemia can be caused by the oxidising effect of a number of different drugs. Prescribed drugs that cause methaemoglobinaemia include local anaesthetics, dapsone, sulphonamides and primaquine. Recreational drugs such as amyl and isobutyl nitrite (‘poppers’) and adulterants in cocaine are also well known to cause methaemoglobinaemia. Low concentrations of methaemoglobin do not require treatment, but higher concentrations can be fatal. When indicated, methylthioninium chloride is the treatment of choice. More complicated cases should be discussed with a local poisons centre.
Source: Adverse Drug Reaction Bulletin - Category: Drugs & Pharmacology Tags: Invited Review Article Source Type: research
ConclusionIt is possible to cannulate and initiate VA ECMO treatment as airborne en route therapy for cardiac arrest and severe CO intoxication in a porcine model.
Source: Air Medical Journal - Category: Emergency Medicine Source Type: research
CONCLUSION: Commonly known sources (fire, charcoal grills) aside, many poisonings by smoking a hookah were observed. This study highlights the importance of considering CO poisoning as a differential diagnosis when encountering patients, especially of younger age, with non-specific neurological symptoms, as well as the importance of early initiation of treatment. A direct correlation between CO-Hb values (whether measured noninvasively or by invasive BGA) and the initial symptoms could not be demonstrated. In total, substantial time expired between the diagnosis and start of treatment of patients transported to a...
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
First, a sort of meta-comment in the form of a shout-out to HCRenewal's intrepid editor, Dr. Roy Poses, for his just-published analysis of what we might call " blogging: rise and fall. " He sees decline reflected in publications long  devoted to health and health policy, yet now flaking off.Methinks, however, despite the usefulness of his overview of recent decades, Dr. P need not fret excessively. Water spilling out of the barrel's lip will slow down once folks come along and punch a whole bunch of little mid-section tweet-holes in it. Information still flows. (Sort of.)  In any case, surely there's ov...
Source: Health Care Renewal - Category: Health Management Source Type: blogs
AbstractCarfentanil is a synthetic fentanyl analogue approved for veterinary use. It is a mu-opioid receptor agonist with an estimated analgesic potency approximately 10,000 times that of morphine and 20-30 times that of fentanyl, based on animal studies. Since 2016, an increasing number of reports describe detection of carfentanil in the illicit drug supply. Little is known about the pharmacology of carfentanil in humans. Its high potency and presumed high lipophilicity, large volume of distribution, and potential active metabolites have raised concerns about the management of people exposed to carfentanil as well as the ...
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
​A 32-year-old man presented to the emergency department complaining of eye pain and decreased vision. He worked for the city and was removing rust and graffiti from a wall with a power washer when the spray ricocheted off the surface and into his eye. He presented with a bottle of the chemical he used, which contained hydrofluoric acid (HF) and other chemicals. He rinsed his eyes with tap water, but experienced persistent decreased vision and pain in both eyes. His exam was remarkable for bilateral injected conjunctiva and excessive tearing.More than 7,000 ocular exposures were reported to U.S. poison control centers pe...
Source: The Tox Cave - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
PMID: 30550470 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Acta Anaesthesiologica Scandinavica, EarlyView.
Source: Acta Anaesthesiologica Scandinavica - Category: Anesthesiology Authors: Source Type: research
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