A fatal and deceiving case of copper sulphate poisoning
Divya Gupta, Sukhyanti Kerai, Mohd S BudooIndian Journal of Anaesthesia 2018 62(10):819-820
PMID: 30550470 [PubMed - in process]
Acta Anaesthesiologica Scandinavica, EarlyView.
Bhavna Gupta, Sukhyanti Kerai, Izan KhanIndian Journal of Anaesthesia 2018 62(11):903-905
Abstract The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. Here, we describe an altered fecal bacterial biota and urine metabolome that follows intoxication with soman, a lipophilic G class chemical warfare nerve agent. Non-anaesthetized Sprague-Dawley male rats were subcutaneously administered soman at 0.8 (sub-seizurogenic) or 1.0 (seizurogenic) of the median lethal dose (LD50) and evaluated for signs of toxicity. Animals were stratified based on seizing activity to evaluate effects of soman exposure on fecal bacterial biota and urine metabolites. Soman ex...
We present the case of a 31-year old male with ingestion of fire extinguisher powder in an attempted suicide. After consulting several poison information centres, the intoxication was initially classified as harmless; nevertheless, the patient was admitted to our intensive care unit for cardiopulmonary monitoring. Subsequently, due to the ingestion of ammonium sulphate and ammonium dihydrogen phosphate containing powder the patient developed severe metabolic acidosis with distinct electrolyte imbalance that required temporary haemodialysis. PMID: 30178118 [PubMed - as supplied by publisher]
We present the hypothesis that this effect is also true of the opioid, fentanyl: there is a causal relationship between the increased popularity of fentanyl as a labor anesthetic in the United States since the 1980 ’s and the current epidemic of fentanyl abuse.
Authors: Wu Q, Xu Q, Jian X, Wang H, He X, Gao B, Wang K, Kan B Abstract Paraquat (methyl viologen, PQ) is highly toxic to humans. Pulmonary fibrosis is the most common cause of death after PQ poisoning. However, no effective therapy is available. The current treatment dilemma and pathology suggest that we should reconsider how to treat the poisoning using other methods, such as immunization. Some clues indicate that immune mechanisms may play important roles in the pathology of PQ poisoning. We implemented a simple experiment to test the hypothesis that activated innate immunity was involved in acute lung injury i...
ConclusionThe findings of the current study revealed that eugenol protected the kidney against PDC-induced acute kidney injury in rats by its antioxidant and anti-inflammatory properties.
In literature, carbon monoxide intoxication (COI) is described by nonspecific symptoms (headache, myalgia, dizziness, weakness, confusion, unconsciousness) like in present patient with unconsciousness . All organs, especially brain and heart, can suffer from COI. On radiological images, hypoxic brain injury can be observed in cerebral cortex and white matter, basal ganglia and especially globus pallidus . In long-term, it can also cause to neuropsychiatric disorders, neurocognitive dysfunctions, and delayed encephalopathy in 0.06 –40% of the survivors.
Conclusion The findings of the current study revealed that eugenol protected the kidney against PDC-induced acute kidney injury in rats by its antioxidant and anti-inflammatory properties.