Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone for postoperative nausea and vomiting in postchemotherapy ovarian cancer surgeries requiring opioid-based patient-controlled analgesia: A randomised, double-blind, active controlled study

Conclusion: Palonosetron with dexamethasone is more effective than ondasetron with dexamethasone for prevention of PONV in post-chemotherapy ovarian cancer surgeries receiving opioid-based patient controlled analgesia.
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research

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CONCLUSIONS: Age was not found to be a prognostic factor for survival. This highlights the necessity of validated geriatric assessment tools predicting functional age and treatment tolerability to avoid undertreatment of elderly patients. PMID: 30157707 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
Abstract OBJECTIVE: To externally validate a model predicting non-home discharge in women undergoing primary cytoreductive surgery (CRS) for epithelial ovarian cancer (EOC). METHODS: Women undergoing primary CRS via laparotomy for EOC at three tertiary medical centers in an academic health system from January 2010 to December 2015 were included. Patients were excluded if they received neoadjuvant chemotherapy, had a non-epithelial malignancy, were not undergoing primary cytoreduction, or lacked documented model components. Non-home discharge included skilled nursing facility, acute rehabilitation facility, ho...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
ConclusionThis mouse model of closed abdomen HIPEC has limited morbidity and could be a useful model to study HIPEC regimens and its effects on peritoneal carcinomatosis.
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
Objectives: 1) To investigate the direct effects of local anesthetics and opioid analgesics alone, as well as in combination with chemotherapeutic agents on ovarian cancer cells in vitro.
Source: Clinical Nutrition ESPEN - Category: Nutrition Authors: Source Type: research
Editor’s Note: This essay contains excerpts from Extreme Measures: Finding a Better Path to the End of Life, coming February 21st, 2017 from Penguin-Random House. A few years ago, while at a family get-together, I sat across from a retired hospice social worker named Terry. I am a physician whose practice alternates between attending on the wards of an inner-city intensive care unit and serving as a consultant on the hospital’s palliative care team. I didn’t set out to practice this uncommon combination of medical specialties. I started out totally dedicated to using the miraculous technologies in my crit...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: End of Life & Serious Illness Health Professionals Hospitals 30-day mortality statistic advance directive Palliative Care Source Type: blogs
BACKGROUND: BriaVax™ (formerly SV-BR-GM-1) is a breast cancer cell line transfected to release GM-CSF. Under FDA BB-IND 10312, the vaccine was tested in 3 metastatic breast, 1 metastatic ovarian cancer patients refractory to previous therapy. Patients received 20 million viable cells ID at 4 sites 48-72 hours after low-dose cyclophosphamide, 300 mg/m2 . Mean cell count was 22.8 x10^6 (18.8-27.6). Mean viability was 90.6%, (84-94%). Interferon-alpha (10,000 u) was injected into each inoculation site after 48 and 96 hrs. The protocol permitted 3 inoculations at 2 week intervals, then, if not showing clearly progressive...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Ongoing Clinical Trials Source Type: research
Background: Neuropathic pain is a common side-effect of chemotherapy. Although precise mechanisms are unclear, oxidative stress and mitochondrial damage are involved. We investigated whether the mitochondria targeted antioxidant, MitoVitE, provided better protection against paclitaxel-induced mitochondrial damage in rat dorsal root ganglion (DRG) cells, than a non-targeted form of vitamin E, Trolox. We also determined whether MitoVitE, compared with duloxetine, could limit paclitaxel-induced mechanical hypersensitivity in rats. Methods: Mitochondrial function was measured in DRG cells exposed to paclitaxel with and without...
Source: British Journal of Anaesthesia - Category: Anesthesiology Authors: Tags: Translational Research Source Type: research
As more women postpone having children until they're older due to career or finding the right partner, some are choosing to freeze their eggs to use later, hoping to beat age-related fertility problems. Will the investment payoff? Maybe. Until recently, eggs were most often frozen for later use for medical reasons. A woman with cancer could opt to preserve her eggs before undergoing chemotherapy or radiation that could permanently damage or destroy her eggs. Freezing for medical reasons has been possible for three decades. Over the last decade, improvement in cryopreservation technology, namely ultra-rapid freezing by vi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Abstract INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are the treatment of choice for selected patients with peritoneal carcinomatosis, which was previously a lethal condition with dismal survival rate. METHODS: We reviewed all CRS and HIPEC procedures performed at our centre from January 1997 to December 2012, with a focus on perioperative events and anaesthetic implications. RESULTS: In total, 111 patients underwent 113 procedures. Mean age of patients was 51.7 (range 14-74) years and 84.1% were women. Mean surgery duration was 9 hours 10 minutes &plus...
Source: Singapore Medical Journal - Category: Journals (General) Authors: Tags: Singapore Med J Source Type: research
Conclusions: Using TachoSil® in women with advanced stage ovarian cancer who underwent radical debulking with retroperitoneal lymph node dissection is associated with a non-statistically significant reduction in the incidence of SLC. A larger-scale randomized controlled study should be conducted to confirm our preliminary results.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
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