6 Minnesota Kids Have Developed a Rare, Polio-Like Illness —and Health Officials Don’t Know Why
Six Minnesota children have recently been diagnosed with a rare, polio-like nervous system disorder that can cause paralysis — and the cluster is concerning and puzzling state health officials. The Minnesota Department of Health (MDH) has since mid-September received a half-dozen reports of children with acute flaccid myelitis (AFM), a severe condition that typically affects kids and can result in muscle weakness or paralysis, respiratory failure and even death, according to a statement. All of the Minnesota patients are younger than 10, and cases have been reported in northeastern and central parts of the state, as well as the Twin Cities area. “That is definitely more than would be expected,” says Kris Ehresmann, director of the infectious disease division at MDH. “To have six cases is really a striking departure from the norm.” Indeed, AFM is exceedingly rare: The Centers for Disease Control and Prevention (CDC) estimates that fewer than one in a million people in the U.S. get it each year, though it has been on the rise since a 2014 outbreak, sparking a CDC investigation. Minnesota typically sees a case or less per year, according to the MDH statement; even in 2014, only three cases were recorded there. AFM affects the spinal cord, impairing muscular function and reflexes, according to the CDC. Arm and leg weakness are common symptoms, but the disease can also involve facial weakness; difficulty swallowing, speaking and passing urine; numbne...
Enteroviruses, including subtype EV-A71, infect the brain, liver, heart, and other organs, causing a myriad of human diseases. This spectrum of disease is thought to be due, in part, to differential binding to host cells, and additional knowledge of enterovirus cell entry is essential for therapeutic development. In this issue of the JCI, Yeung et al. provide evidence of a novel EV-A71 entry factor, a host-produced tryptophan tRNA synthetase (hWARS), that facilitates entry of multiple subtypes of enteroviruses. hWARS is a cytoplasmic enzyme that is essential for translation but also upregulated and secreted during inflamma...
Enterovirus A71 (EV-A71) receptors that have been identified to date cannot fully explain the pathogenesis of EV-A71, which is an important global cause of hand, foot, and mouth disease and life-threatening encephalitis. We identified an IFN-γ–inducible EV-A71 cellular entry factor, human tryptophanyl-tRNA synthetase (hWARS), using genome-wide RNAi library screening. The importance of hWARS in mediating virus entry and infectivity was confirmed by virus attachment, in vitro pulldown, antibody/antigen blocking, and CRISPR/Cas9-mediated deletion. Hyperexpression and plasma membrane translocation of hWARS were obs...
A child from Florida is the first person to die of the flu this season. The child was unvaccinated with no known underlying medical conditions. But a new survey shows more parents don't see the benefits of the flu vaccine. CBS News medical contributor Dr. Tara Narula has more.
BOSTON (CBS) – As we head into the heart of flu season, Dr. Mallika Marshall provides the facts you need to know to keep you and your family safe. The time to get vaccinated against the flu is now. The vaccine is widely available at doctor’s offices and pharmacies and it take a couple of weeks to build immunity to the flu and the flu season has started. Massachusetts has seen at least 80 lab-confirmed cases of influenza so far, which is typical for this time of year. Plus, a child in Florida has already died from the flu. She was healthy but had not been vaccinated. Getting the flu shot is the best way to prote...
as rate of new cases has doubled
A child in Florida who wasn't vaccinated has died from getting the flu.
So far, 38 children in 16 states have been diagnosed with acute flaccid myelitis. Health officials have been unable to determine the specific virus it is linked to - or how to treat symptons.
World Health Organization (WHO) Director-General, Dr Tedros Adhanom Ghebreyesus, has called an Emergency Committee meeting on the Ebola virus outbreak in the Democratic Republic of the Congo (DRC), which has already claimed around 130 lives.
Government staff in the central African country will be trained how to spot, treat and prevent Ebola amid fears people crossing the border from the DRC could bring the deadly virus with them.
Personnel from the US Centers for Disease Control and Prevention who have been stationed in the Democratic of Congo to help control the ongoing Ebola outbreak have been pulled back from the worst impacted areas due to safety concerns, a US government official familiar with the situation told CNN Monday.
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