Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing

Publication date: Available online 6 October 2018Source: International Journal of PharmaceuticsAuthor(s): Guilherme T. Voss, Matheus S. Gularte, Ane G. Vogt, Janice L. Giongo, Rodrigo A. Vaucher, Joanna V.Z. Echenique, Mauro P. Soares, Cristiane Luchese, Ethel A. Wilhelm, André R. FajardoAbstractWound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. The starting materials and the cellulose-based films were characterized in detail. As assessed, vitamin C can be released from the Cel-PVA/VitC and Cel-PVA/VitC/Prop films in a controlled manner. In vitro antibacterial activity studies showed a reduction of bacteria counts (Escherichia coli and Staphylococcus aureus) after Cel-PVA/VitC, Cel-PVA/Prop, and Cel-PVA/VitC/Prop treatments. Moreover, we examined the antibacterial and wound healing properties of the cellulose-based films in a streptozotocin (STZ)-induced diabetic animal model. Diabetic mice exhibited impaired wound healing while the Cel-PVA/VitC/Prop treatment increased the wound closure. A marked reduction in bacterial counts present in the wound environment of diabetic mice was observed after Cel-PVA/VitC, Cel-PVA/Prop and Cel-PVA/VitC/Prop treatment. Histological analysis demonstrated that the non...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research