A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 β-lactamase.

This study describes an isolate of Aeromonas hydrophila harbouring an acquired gene encoding the carbapenemase GES-24. This isolate was obtained from an inpatient in Okinawa, Japan, with no apparent record of travelling overseas. The minimum inhibitory concentrations of carbapenems against this isolate were 8 µg ml-1 for imipenem and 16 µg ml-1 for meropenem. Recombinant GES-24 hydrolyzed all of the tested β-lactams, including imipenem and meropenem. The genomic environment surrounding blaGES-24 was intI1-blaGES-24-aac(6')-IIc-qacEdelta1-sulI-orfX-tetR-tetE. This is the first report of A. hydrophila producing a GES-type carbapenemase. PMID: 30289383 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30289383?dopt=Abstract

Source: Journal of Medical Microbiology - October 5, 2018 Category: Microbiology Authors: Uechi K, Tada T, Sawachi Y, Hishinuma T, Takaesu R, Nakama M, Nakasone I, Kirikae T, Fujita J Tags: J Med Microbiol Source Type: research