Association Networks in a Matched Case-Control Design – Co-occurrence Patterns of Preexisting Chronic Medical Conditions in Patients with Major Depression versus their Matched Controls

ConclusionAssociation networks in a matched case-control design can provide a high-level comparison of comorbid features after adjusting for confounding factors, thereby supplementing traditional clinical study approaches. We demonstrate the differential co-occurrence pattern of chronic medical conditions in patients with MDD and prioritize the chronic conditions that have statistically significant interactions in regression models for depression.Graphical abstract
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research