Association of symptom severity, insight and increased pharmacologic side effects in acutely hospitalized patients with schizophrenia

Many studies have shown that more severe symptoms and poorer insight are associated with poor treatment compliance in schizophrenia while severe symptoms may result in higher medication dosages. Since pharmacologic side effects may accompany greater medication compliance and higher medication dosage, the relationship between symptoms, insight and side effects deserves study.
Source: Comprehensive Psychiatry - Category: Psychiatry Authors: Source Type: research

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Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Source: Cell - Category: Cytology Source Type: research
We report a case from Nepal where psychogenic polydipsia was complicated to hyponatremia and lead to seizure episodes. We emphasize on asking a routine question about polydipsia in every patient of Schizophrenia in clinics. PMID: 31827965 [PubMed]
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
Publication date: Available online 11 December 2019Source: Schizophrenia Research: CognitionAuthor(s): Hanna Kucwaj, Adam ChuderskiAbstractProportional analogies between four objects (e.g., a squirrel is to tree as a golden fish is to? aquarium) were examined in 30 schizophrenia patients and 30 healthy controls. Half of the problems included distracting response options: remote semantic associates (fishing rod) and perceptually similar salient distractors (shark). Although both patients and controls performed fairly accurately on the no-distraction analogies, patients’ performance in the presence of distractors was d...
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
In a 20-year study, most cognitive functions in 445 individuals with psychotic disorders declined, according to a report published inJAMA Psychiatry.“Compared with a matched control group, year-20 cognitive outcomes were poor in [participants with] psychotic disorders, especially for older participants,” wrote Anne-Kathrin J. Fett, Ph.D., of the University of London and colleagues. “These results provide the first comprehensive picture of long-term cognitive changes and associated clinical and functional outcomes in psychotic disorders.”The participants were part of the Suffolk County Mental Health ...
Source: Psychiatr News - Category: Psychiatry Tags: Anne-Kathrin J. Fett cognitive decline Ph.D. psychotic disorders Suffolk County Mental Health Project Source Type: research
Conclusion: Our findings provide evidence of lower testosterone and free-testosterone levels and increased SHBG levels in drug-naïve, first-episode males with psychosis.KEY POINTSReduced testosterone and free-testosterone levels in drug-naive, first-episode males with psychosis.Increased SHBG levels in drug-naive first-episode males with psychosis.No difference in FSH, LH and E2 levels between drug-naive first episode males with psychosis and controls.No difference in testosterone, free-testosterone and SHBG levels between drug-naive, first-episode women with psychosis and controls. PMID: 31825684 [PubMed - as supplied by publisher]
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
Conclusion: Our results demonstrated that a significant percentage of patients affected by both mood disorders and schizophrenia shows relevant social dysfunction. Social dysfunction is related, but not completely explained by psychopathological severity. In several patients, it tends to persist also during remission state. Socio-demographic and lifestyle factors were also found to play a role and should therefore be taken into consideration in further studies investigating social dysfunction.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Conclusions. These results indicate that in this sample of early psychosis outpatient group, reductions in frequency MMN but not in duration MMN index clinical status. The relationship between age at first hospitalization and MMN frequency and duration amplitude and latency indicates that neurodevelopmental stage, auditory function, and clinical status are tightly linked. PMID: 31826666 [PubMed - as supplied by publisher]
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Tags: Clin EEG Neurosci Source Type: research
Background: The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality.Materials and Methods: GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control (C) and age-matched subjects (T) of schizophrenia (N = Hippocampus [HIP]: C-15, T-18, Prefrontal cortex [PFC]: C-15, T-19, Associative striatum [STR]: C-18, T-18). Bio-conductor&mdash...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and Schizophrenia mainly target disease symptoms. Thus, there is an urgent need to develop novel therapeutics that can delay, halt or reverse disease progression. AD, HD, PD, and schizophrenia are characterized by elevated oxidative and nitrosative stress, which play a central role in pathogenesis. Clinical trials utilizing antioxidants to counter disease progression have largely been unsuccessful. Most antioxidants are relatively non-specific and do not adequately t...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: NBOMe ingestion implicates the risk of peripheral vasospasms with severe, limb-threatening ischemia.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Brief Report Source Type: research
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