Relationship of clinical course of illness variables to medical comorbidities in 900 adult outpatients with bipolar disorder

Medical illnesses are highly comorbid with bipolar disorder, but their relationship to illness characteristics has not been previously delineated.
Source: Comprehensive Psychiatry - Category: Psychiatry Authors: Source Type: research

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Publication date: Available online 9 December 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Hossein Ayazi, Omid Akhavan, Mohammad Raoufi, Reyhaneh Varshochian, Najmeh Sadat Hosseini Motlagh, Fatemeh AtyabiAbstractFree polymer graphene aerogel nanoparticles (GA NPs) were synthesized by using reduction/aggregation of graphene oxide (GO) sheets in the presence of vitamin C (as a biocompatible reductant agent) at a low temperature (40 °C), followed by an effective sonication. Synthesis of GA NPs in doxorubicin hydrochloride (DOX)-containing solution results in the simultaneous synthesis and drug loadi...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
There is no time more joyous and stressful as the end of year holidays. As we fast approach the holidays this year it’s time to start thinking about how you’ll navigate family parties and other familial obligations. In this episode, we give our best tips for making holiday parties less stressful and how to decide if not going is the best option for you.  It’s rough out there, but we care about you and we wish you a happy, healthy holiday season. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bi...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Depression Family General Holiday Coping Not Crazy Podcast Source Type: blogs
Bipolar disorder (BD) is characterized by recurrent episodes of depression and mania/hypomania alternating with intervals of well-being. The neurobiological underpinnings of BD are still veiled although there ...
Source: International Journal of Bipolar Disorders - Category: Psychiatry Authors: Tags: Study Protocols Source Type: research
CONCLUSIONS: Our findings indicate that increased physical activity and more adequate sleep are associated with increased brain size, better cognitive function and more stable temperament in BP-I patients and their non-BP-I relatives. Additionally, we found evidence for pleiotropy of several actigraphy-behavior and actigraphy-brain phenotypes, suggesting a shared genetic basis for these traits. PMID: 31813409 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Translational Psychiatry, Published online: 09 December 2019; doi:10.1038/s41398-019-0666-4Hepatic gene expression explains primary drug toxicity in bipolar disorder
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
ConclusionX chromosome association studies should employ methods which account for its unique biology. Future work is needed to validate the identified associations with BD, to formally assess the performance of both approaches under different true genetic architectures, and to apply these approaches to study sex differences in other conditions.
Source: Biology of Sex Differences - Category: Biology Source Type: research
Authors: Silveira C, Guedes R, Maia D, Curral R, Coelho R Abstract Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients' quality of life (QoL). Depression is a highly prevalent condition in MS patients, associated with poorer adherence to treatment, decreased functional status and QoL, and increased suicide risk. Diagnosis and treatment of this disorder is challenging because of symptom overlap. Other prevalent psychiatric comorbidities are anxiety disorders, bipolar disorder...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Functional coupling of M1 muscarinic acetylcholine receptor to Gαq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. Eur Arch Psychiatry Clin Neurosci. 2019 Dec 05;: Authors: Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA Abstract Accumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced Gαi/o and Gαq/11 activation was identified in postmortem human prefrontal cortical ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
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