Venous Thromboembolism is Associated with Lack of Vitamin D Supplementation in Patients with Spinal Cord Injury and Low Vitamin D Levels

The role of vitamin D (VitD) in the pathogenesis of venous thromboembolism (VTE) and prevalence of low VitD (LVitD) in spinal cord injury (SCI) has motivated VitD testing and supplementation. This is an exploratory study of data collected at a time before the routine clinical practice of VitD supplementation, allowing for evaluation of the natural history of LVitD levels in patients with SCI.
Source: PM and R - Category: Rehabilitation Authors: Source Type: research

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​BY ALI OZCAN, MD; AYUSH GUPTA, MD; ISABEL NEACATO, MD; DAVID DONALDSON, DO; &SHANNA JONES, MDA 17-year-old boy presented to the pediatric emergency department complaining of a right shoulder injury and right clavicular pain for two hours. The pain started after he checked another player into the boards while playing hockey. He had no head injury, loss of consciousness, or other trauma. He took 600 mg of ibuprofen with no relief, so he came to the ED.He had no past medical or surgical problems, and reported his pain as 4/10 over the clavicle region. His review of system was otherwise negative. The patient's vitals we...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Boris Vladimir Cabrera Nanclares, Huber Said Padilla-Zambrano, Ayman El-Menyar, Luis Rafael Moscote-Salazar, Sagar Galw.ar, Ranabir Pal, Amrita Ghosh, Amit Agrawal, Mendoza-Flórez RomarioJournal of Emergencies, Trauma, and Shock 2019 12(2):150-154 The risk and outcome of deep vein thrombosis (DVT) in patients who sustained spinal cord injury (SCI) remain a challenge. We aimed to assess the incidence, risk, burden, and prophylaxis of DVT after SCI. Thirty-nine studies were identified from among 250 relevant articles based on firstly, broad criterion of DVT among SCI cases. secondly, “risk factors” impactin...
Source: Journal of Emergencies, Trauma and Shock - Category: Emergency Medicine Authors: Source Type: research
Spinal Cord, Published online: 17 May 2019; doi:10.1038/s41393-019-0293-1Comparison of two pharmacological prophylaxis strategies for venous thromboembolism in spinal cord injury patients: a retrospective study
Source: Spinal Cord - Category: Research Authors: Source Type: research
Abstract The patients with spinal cord injury (SCI) suffered significantly higher risk of deep vein thrombosis (DVT) than normal population. The aim was to assess the clinical significance of macrophage migration inhibitory factor (MIF) as the risk factor for DVT in acute SCI patients. 207 Chinese patients were enrolled in this study, including thirty-nine (39) patients (18.8 %; 95 %CI: 13.5 %-24.2 %) diagnosed as DVT at the follow-up of 1 month. Nine (9) of the 39 patients (23.1%) were suspected of thrombosis before the screening. The MIF levels in plasma of DVT patients were significantly higher than DVT-free pa...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: In acute traumatic SCI, older age and more severe neurological impairment (AIS A, B, and C) are independent risk factors for positive duplex screening for any (proximal and/or distal) DVT detected on rehabilitation admission. Individuals with an acute distal DVT have a high likelihood for future thrombus progression. Routine surveillance for these patients may be warranted. PMID: 30939080 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Semin Thromb Hemost DOI: 10.1055/s-0039-1678720Patients with acute spinal cord injury (SCI) have the highest risk of venous thromboembolism (VTE) among hospitalized patients. The incidence of total deep vein thrombosis ranges from 50 to 100% in untreated patients and pulmonary embolism is the third most common cause of mortality in these patients. The pathophysiology of the increased risk of VTE is explained by venous stasis after injury, endothelial vessel wall injury from surgery, and a hypercoagulable state associated with trauma. The current thromboprophylaxis options are limited, with low-molecular-weight heparin (LMW...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
Publication date: Available online 6 October 2018Source: PM&RAuthor(s): Reza Ehsanian, Molly A. Timmerman, Jerry M. Wright, Stephen McKenna, Ben Dirlikov, James CrewAbstractBackgroundThe role of vitamin D (VitD) in the pathogenesis of venous thromboembolism (VTE) and prevalence of low VitD (LVitD) in spinal cord injury (SCI) has motivated VitD testing and supplementation. This is an exploratory study of data collected at a time before the routine clinical practice of VitD supplementation, allowing for evaluation of the natural history of LVitD levels in patients with SCI.ObjectiveTo determine if VitD supplementation in per...
Source: PMandR - Category: Rehabilitation Source Type: research
Authors: Cichos KH, Lehtonen EJ, McGwin G, Ponce BA, Ghanem ES Abstract INTRODUCTION: Orthopaedic surgeons are wary of patients with neuromuscular (NM) diseases as a result of perceived poor outcomes and lack of data regarding complication risks. We determined the prevalence of patients with NM disease undergoing total joint arthroplasty (TJA) and characterized its relationship with in-hospital complications, prolonged length of stay, and total charges. METHODS: Data from the Nationwide Inpatient Sample from 2005 to 2014 was used for this retrospective cohort study to identify 8,028,435 discharges with total jo...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
ConclusionsEarly treatment, prevention of associated complications and individualized patient-targeted rehabilitation programs provided by a specialized interdisciplinary team are crucial to optimize the outcome after SCI.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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