Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder

Studies on bipolar disorder (BD) have suggested the involvement of immune system dysfunctions in the disease activity of BD (Goldsmith et al., 2016). Furthermore, progressive neuropathological processes (Berk et al., 2011) and various mood phases (Tsai et al., 1999; 2012; 2014) in BD may be linked to alterations in inflammatory cytokines. Microglia, the concentration of which is particularly high in the hippocampus, primarily mediate innate immunity and are involved in most inflammatory processes in the central nervous system (CNS) (Badoer, 2010; Perry et al., 1993).

Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Shang-Ying Tsai, Ariel G. Gildengers, Jung-Lung Hsu, Kuo-Hsuan Chung, Pao-Huan Chen, Yu-Jui Huang Tags: Research paper Source Type: research