The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: a randomized placebo-controlled study

Bipolar depression is challenging to treat, partly due to few available treatments (Grunze et al., 2013). Therefore, search for new treatment options are warranted, and over the recent years, N-acetylcysteine (NAC) has been examined in bipolar disorder (BD) and other mental and neuropsychiatric disorders (Berk et al., 2013; Dean et al., 2011; Deepmala et al., 2016; Minarini et al., 2017). Additionally, NAC has been used in other areas of medicine for almost four decades (D. and Conner, 1978) and is currently used for treating paracetamol overdose (Dringen and Hirrlinger, 2003), chronic obstructive pulmonary disease (Atkuri et al., 2007) and Human Immunodeficiency Virus-infection (Dodd et al., 2008).
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research