Programmed death ligand 1 expression in human intrahepatic cholangiocarcinoma and its association with prognosis and CD8+ T-cell immune responses

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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Authors: Li X, Wu N, Ji H, Huang Y, Hu H, Li J, Mi S, Duan S, Chen X Abstract The AGTR1 gene encodes angiotensin II receptor type 1, which is involved in cardiovascular diseases such as coronary heart disease (CHD). In the current study, we analyzed AGTR1 methylation level in a Han Chinese population by SYBR green-based quantitative methylation-specific PCR (qMSP). We collected blood samples from 761 CHD patients and 398 non-CHD controls at the Ningbo First Hospital. A data mining analysis was also performed to explore the association between AGTR1 methylation and AGTR1 gene expression, using datasets from the cBio...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Conclusions: In conclusion, activation of NF-κB/p65 mimicking chronic inflammation provokes the formation of liver carcinoma. Collateral disruption of Trp53 supports tumor progression and influences tumor differentiation and heterogeneity.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract In 2005, the network decided to increase its number of target diseases to include other helminthic zoonoses such as fascioliasis, clonorchiasis, opisthorchiasis, paragonimiasis and cysticercosis and in the process expanding membership to include South Korea, Vietnam, Thailand and Japan. NTDs were eventually included as awareness is heightened on these diseases affecting poor and developing countries. Researches on clonorchiasis and opisthorchiasis unravel the mechanism by which these diseases eventually predispose to cholangiocarcinoma. The liver cancer associated with these liver fluke infections necessi...
Source: Advances in Parasitology - Category: Parasitology Authors: Tags: Adv Parasitol Source Type: research
Abhay K. Pandey Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one of the major bioactive compounds present in various plants. Ellagitannins belong to the hydrolyzable tannins, a group of polyphenols. Corilagin shows broad-spectrum biological, and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, and antitumor actions. Natural compounds possessing antitumor activities have attracted significant attention for treatment of cancer. Corilagin has shown inhibitory activity against the growth of numerous cancer cells by prompting cell cycle arr...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Cholangiocarcinoma (CCA) is an exceptionally aggressive cancer arising from the biliary duct epithelium and CCA represent approximately 3 to 5% of all malignancies of the gastrointestinal system. CCA are classically sub-divided into three groups depending on the anatomical site of origin: intrahepatic CCA (iCCA), perihilar CCA (pCCA) and distal CCA (dCCA). iCCAs classically arise above the second-order bile ducts, whereas the anatomical point of distinction between perihilar cholangiocarcinomas (pCCAs) and distal cholangiocarcinomas (dCCAs) is the cystic duct [1 –4,76].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Conclusion.This study demonstrates that merestinib has a tolerable safety profile and potential anticancer activity and warrants further clinical investigation.Implications for Practice.Merestinib treatment in patients with advanced cancer demonstrated an acceptable safety profile and potential antitumor activity, supporting its future development in specific disease populations as a monotherapy and/or in combination with other therapies.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Head and Neck Cancers, Melanoma and Cutaneous Malignancies, Gastrointestinal Cancer New Drug Development and Clinical Pharmacology Source Type: research
Circular RNAs (circRNAs) play a vital role in cancers. Accumulated evidences showed that the physiological condition of cells can be reflected by the circRNAs in the exosomes they secrete, and these exosomal circRNAs can be captured by the receptor cells, thereby inducing a series of cellular responses. We performed qRT-PCR to detect the expression level of circ-0000284 in cholangiocarcinoma cell lines, tissues and plasma exosomes. Then the direct interaction between circ-0000284 and miR-637 was investigated through dual-luciferase reporter assay, RIP assay and FISH assay. Subsequently, EdU, migration, invasion assay, flow...
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research
ConclusionWe provide evidence that LRRK2 was an independent prognostic factor for ICC in humans by participating in the proliferation and metastasis of ICC cells.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Conditions:   Gastrointestinal Cancer;   Colorectal Cancer;   Pancreatic Adenocarcinoma;   Gastric Cancer;   Esophageal Cancer;   Cholangiocarcinoma;   Hepatocellular Carcinoma;   Neuroendocrine Tumors;   GIST, Malignant Interventions:   Behavioral: Serious Illness Conversation Guide (SICG);   Behavioral: Quality of Life (QOL) survey Sponsor:   Stanford University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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