Three mononuclear Cu (II) complexes based on p-tolylmethanamine Schiff bases: In-vitro cytotoxicity, DNA binding ability, nuclease activity and antibacterial studies

Publication date: Available online 5 October 2018Source: Inorganic Chemistry CommunicationsAuthor(s): D. Shiva Shankar, Aveli Rambabu, Narendrula Vamsikrishna, Nirmala Ganji, Sreenu Daravath, ShivarajAbstractHerein, we have reported three novel mononuclear copper (II) complexes 1. [Cu(L1)2], 2. [Cu(L2)2] and 3 [Cu(L3)2] where, L1H = (2-(4-methylbenzylimino)methyl)-4-nitrophenol, C15H14N2O3)), L2H = (2-(4-methylbenzylimino)methyl)-4-chlorophenol, C15H14ClNO)) and L3H = (2-(4-methylbenzylimino)methyl)-4,6-dichlorophenol, C15H13Cl2NO)) have been characterized by several physicochemical techniques. Having a base of spectroscopic and analytical data, complexes 1, 2 and 3 exhibited square planar geometry where Schiff bases acts as a bi-dentate NO donar ligands. DNA biding and nuclease activity studies against CT-DNA and supercoiled pBR322-DNA respectively revealed an intercalative mode of binding and also cleave efficient manner. Moreover, synthesized compounds was investigated for their in-vitro cytotoxic potential against human breast cancer cell (MCF-7) and oral cancer cell (KB3) using cis-platin as standard drug under MTT assay, results revealed that the biological potency of synthesized compounds as well as antibacterial activity.Graphical abstract

Source: Inorganic Chemistry Communications - October 5, 2018 Category: Chemistry Source Type: research