Assessing Genome-wide Copy Number Aberrations and Copy-Neutral Loss-of-Heterozygosity as Best Practice: An Evidence-Based Review from the Cancer Genomics Consortium Working Group for Plasma Cell Disorders

Plasma cell neoplasms (PCNs) are characterized by the uncontrolled clonal expansion of genetically altered plasma cells. These diseases include the precursor lesion monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, plasma cell myeloma (or multiple myeloma), plasmacytoma, monoclonal immunoglobulin deposition diseases (amyloidosis), and PCNs associated with paraneoplastic syndromes. While karyotype and fluorescence in situ hybridization (FISH) analyses have been instrumental in determining prognosis and guiding therapy, the clinical significance of new and emerging molecular markers raise the need to explore expanded and alternative testing algorithms to guide care.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Review Article Source Type: research