Efficacy of a fibrin sealant (Tissucol Duo®) for the prevention of lymphocele after laparoscopic pelvic lymphadenectomy: a randomised controlled trial

Publication date: Available online 5 October 2018Source: Journal of Minimally Invasive GynecologyAuthor(s): Ibon Jaunarena, Ruben Ruiz, Mikel Gorostidi, Paloma Cobas, Marisa Avila, David Del Valle, Juan Cespedes, Arantxa LekuonaABSTRACTStudy ObjectiveTo assess the efficacy of Tissucol Duo® (Baxter AG) fibrin sealant in decreasing the incidence of lymphocele (LC) after pelvic laparoscopic lymph node dissection using harmonic shears.Design classificationRandomized controlled trial (Canadian Task Force Classification level I)SettingTertiary referral and educational center.PatientsA double blind randomized controlled study was conducted (February 2012-June 2016) including 74 patients randomizing the use of sealant per hemipelvis.InterventionFollowing bilateral pelvic lymphadenectomy, a fibrin sealant was used in one hemipelvis but not the other, being applied in 41 (55.4%) left and 33 (44.6%) right hemipelvises. The primary outcome was the incidence of LC after surgery in symptomatic and asymptomatic patients. Imaging (ultrasound, computed tomography and magnetic resonance) was performed to detect LC at 3, 6 and 12 months after surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research