Association of ERG/PTEN status with biochemical recurrence after radical prostatectomy for clinically localized prostate cancer

AbstractWe have previously demonstrated a significant correlative relationship betweenPTEN deletion andERG rearrangement, both in the development of clinically localized prostate cancers and metastases. Herein, we evaluate the cooperative role of ERG and PTEN in oncological outcomes after radical prostatectomy for clinically localized prostate cancer. We evaluatedERG andPTEN status using three previously described cohorts. The first cohort included 235 clinically localized prostate cancer cases represented on tissue microarrays (TMA), evaluated using previously validated FISH assays forERG andPTEN. The second cohort included 167 cases of clinically localized prostate cancer on TMAs evaluated forPTEN by FISH, and for PTEN and ERG by dual IHC. The third cohort comprised 59 clinically localized prostate cancer cases assessed by array comparative genomic hybridization (aCGH). Kaplan –Meir plots and long rank tests were used to assess the association ofERG andPTEN status with biochemical recurrence after radical prostatectomy for clinically localized prostate cancer. Of the 317 cases eligible for analyses with evaluableERG andPTEN status, 88 (27.8%) patients developed biochemical recurrence over a median follow-up of 5.7  years. Overall, 45% (142/317) of cases demonstratedERG rearrangement and 20% (62/317) of cases demonstratedPTEN loss. Hemizygous and homozygous deletion ofPTEN was seen in 10% (18/175) and 3% (5/175) ofERG-negative cases, respectively. In contrast, hemizygous ...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research