Association of CILP , COL9A2 and MMP3 Gene Polymorphisms with Lumbar Disc Degeneration in an Indian Population

In this study, we analyzed the role of a few important single nucleotide polymorphisms in cartilage intermediate layer protein (CILP), collagen 9A2 (COL9A2) and matrix metalloproteinase 3 (MMP3) genes in LDD from an Indian population. Two hundred patients with LDD and 200 healthy controls were recruited for the study. Genotyping was performed by allelic discrimination assay. The rs2073711 polymorphism (CILP gene - GG genotype) was associated with reduced risk of LDD in the Indian population (OR  = 0.43,p = 0.016). The rs591058 polymorphism (MMP3 gene - TT genotype) is found to be associated with lower risk among women (OR  = 0.34,p = 0.041). No significant association was found betweenCOL9A2 polymorphism rs7533552 and the risk of LDD. We conclude that theCILP gene polymorphism (rs2073711) is associated with a lower risk of LDD, theMMP3 (rs591058) gene polymorphism is associated with LDD among women, and the TT genotype confers a lower risk of LDD.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research